Pathogenic role of CADM-140 antigen (MDA5) in patients with dermatomyositis

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Anti-CADM-140/MDA5 (Melanoma Differentiation-Associated Gene 5) antibody is a recently-reported antibody that recognized a 140 kDa polypeptide in patients with dermatomyositis (DM). This autoantibody has a close association with rapidly progressive interstitial lung disease (RP-ILD) and may be useful marker for presence of RP-ILD. In this study, we demonstrated close association between anti-CADM-140/MDA5 antibody titer by ELISA and RP-ILD disease activity in patients with DM and RP-ILD. Our findings also highlight the usefulness of this antibody not only in the prediction of RP-ILD but also in monitoring of the disease activity and prediction of disease outcome in daily clinical practice. Moreover, our data might be suggested that complexes of MDA5 and anti-CADM-140/MDA5 antibody might play a significant role in pathogenesis of RP-ILD and DM rather than being an epiphenomenon.