Neuronal metabolic changes in preterm infants assessed using multi-voxel proton magnetic resonance spectroscopy

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This study aimed to reveal the difference of brain metabolic change using MRS within the first year of life between normal development and psychomotor retardation in preterm and low birth weight infants.We enrolled 17 infants who were born at 29 weeks gestation weighing 1,108g.They underwent MRS at 39-46 postconceptional weeks(PCW),47-60PCW,75-89PCW,and 90-104PCW.MRS was performed through the frontal lobe(FL)and the basal ganglia and thalamus(BG+Th).N-acetylaspartate(NAA)/creatine(Cr),choline/Cr and myoinositol(Ins)/Cr were determined.Thirteen infants had normal DQ and MRI were formed the contral group.Four infants had abnormalitied on MRI were classified as test subjects.The NAA/Cr in the BG+Th of two test subjects who were developmental delay was below -2SD of the mean of the controls from 61-74PCW and Ins/Cr was above +2SD at 90-104PCW.