Neuronal metabolic changes in preterm infants assessed using multi-voxel proton magnetic resonance spectroscopy

使用多体素质子磁共振波谱评估早产儿的神经元代谢变化

• 批准号: 23591513
• 负责人: AKASAKA MANAMI
• 金额: $ 3.41万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591513/
• 关键词: 超高磁場装置; 磁気共鳴分光法; 早産児; GABA; 発達障害; MRS; 低出生体重児; N-acetylaspartate; 基底核; 発達予後; 7T MRI; γ-aminobutyric acid; 7Tesla MRI; 超高解像度核磁気共鳴分光法; 早産時; 極低出性体重児; 脳室周囲白質軟化症; 点頭てんかん; 極低出体重児

This study aimed to reveal the difference of brain metabolic change using MRS within the first year of life between normal development and psychomotor retardation in preterm and low birth weight infants.We enrolled 17 infants who were born at 29 weeks gestation weighing 1,108g.They underwent MRS at 39-46 postconceptional weeks(PCW),47-60PCW,75-89PCW,and 90-104PCW.MRS was performed through the frontal lobe(FL)and the basal ganglia and thalamus(BG+Th).N-acetylaspartate(NAA)/creatine(Cr),choline/Cr and myoinositol(Ins)/Cr were determined.Thirteen infants had normal DQ and MRI were formed the contral group.Four infants had abnormalitied on MRI were classified as test subjects.The NAA/Cr in the BG+Th of two test subjects who were developmental delay was below -2SD of the mean of the controls from 61-74PCW and Ins/Cr was above +2SD at 90-104PCW.

对17例胎龄29周、胎龄39~46周、胎龄47~60周、胎龄75~89周、胎龄90~104周的早产儿和低出生体重儿进行磁共振波谱检查，通过额叶、基底节和thalamus(BG+Th).N-acetylaspartate(NAA)/creatine(Cr)，进行磁共振波谱检查，探讨早产儿和低出生体重儿在出生一年内大脑代谢变化的差异测定胆碱/肌醇(Ins)/肌醇(Ins)/肌酸比值。13例DQ和MRI正常的婴儿为对照组，4例MRI异常的婴儿为实验对象。2例发育迟缓的受试者BG+Th的NAA/Cr61-74PCW低于-2SD，INS/Cr90-104PCW高于+2SD。

项目成果

1.5Tesla MRSによる早産低出生体重児の脳代謝評価

1.5 Tesla MRS对早产低出生体重儿脑代谢的评估

• 作者: 赤坂真奈美;荒谷菜海;亀井 淳;他
• 通讯作者: 他

早産児ビリルビン脳症の核磁気共鳴スペクトロスコピー（MRS）所見

早产儿胆红素脑病的磁共振波谱（MRS）表现

• 发表时间: 2011
• 作者: Okumura A;Nakagawa S;Kawashima H;Muguruma T;Saito O;Fujimoto J;Toida C;Kuga S;Imamura T;Shimizu T;Kondo N;Morishima T;亀井 淳
• 通讯作者: 亀井 淳

Neuronal metabolic changes in preterm infants assessed using multi-voxel proton magnetic resonance spectroscopy

使用多体素质子磁共振波谱评估早产儿的神经元代谢变化

• 发表时间: 2014
• 作者: Manami Akasaka;Atsushi Kamei;et al
• 通讯作者: et al

Proton magnetic resonance spectroscopic images in preterm infants with bilirubin encephalopathy.

患有胆红素脑病的早产儿的质子磁共振波谱图像。

• DOI: 10.1016/j.jpeds.2011.09.036
• 发表时间: 2012
• 期刊: The Journal of pediatrics
• 作者: A. Kamei;M. Sasaki;Manami Akasaka;Nami Soga;K. Kudo;S. Chida
• 通讯作者: S. Chida

Manami Akasaka, Atsushi Kamei,Nami Soga et al

赤坂真奈美、龟井敦、曾我奈美等人

• 发表时间: 2013
• 作者: Segawa M;Nomura Y;Hayashi M;The metabolic Changes of 1H-MR Spectroscopy in Preterm Low Birth Weight Infants：2 . Five cases with brain injury
• 通讯作者: The metabolic Changes of 1H-MR Spectroscopy in Preterm Low Birth Weight Infants：2 . Five cases with brain injury