课题基金 / 基金详情

Analysis and therapeutic research for growth impairment accompanied with chronic inflammatory syndrome of children as dysregulation of proinflammatory cytokines

Analysis and therapeutic research for growth impairment accompanied with chronic inflammatory syndrome of children as dysregulation of proinflammatory cytokines
促炎细胞因子失调所致儿童慢性炎症综合征生长障碍分析及治疗研究
批准号:
23591546
负责人:
YOKOTA Shumpei
金额:
$3.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

项目摘要

项目成果

YOKOTA Shumpei的其他基金

相关文献

中文摘要
翻译
全身性幼年特发性关节炎(sJIA)伴发的生长障碍被认为与IL-6(引起全身性炎症的关键细胞因子)抑制软骨细胞增殖和皮质类固醇抑制骨延伸有关。Tocilizumab是一种抗IL-6受体抗体,2008年在日本获得批准,目前主要用于治疗激素难治性或依赖性sJIA。我们调查了45例服用TCZ的sJIA患者的身高和身高增长速度,分析了它们与年龄、性别、疾病持续时间和皮质类固醇暴露等多个因素的相关性,身高标准差评分(HTSDS)与疾病持续时间呈负相关,皮质类固醇减少与身高增长速度改善之间存在强相关性。
英文摘要
Growth impairment accompanied with systemic juvenile idiopathic arthritis (sJIA) is thought to be associated with suppression of proliferation of chondrocyte by IL-6, the key cytokine causing systemic inflammation, and suppression of bone extension by corticosteroid. Tocilizumab, anti-IL-6 receptor antibody, was approved in 2008 in Japan, so now bloadly used as treatment for steroid-refractory or -dependent sJIA. We have investigated height and height velocity of 45 sJIA patient administered with TCZ and analyzed correlation between them and several factors such as age, gender, disease duration and corticosteroid exposure, then inverse correlation between standard deviation score for height (HTSDS) and disease duration and strong correlation between reduction of corticosteroid and improvement of height velocity.
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会议论文
DOI: 10.1007/s10067-012-2082-5
发表时间: 2012-12
期刊: CLINICAL RHEUMATOLOGY
影响因子: 3.4
作者: [Imagawa, Tomoyuki, Takei, Syuji, Umebayashi, Hiroaki, Yamaguchi, Kenichi, Itoh, Yasuhiko, Kawai, Toshinao, Iwata, Naomi, Murata, Takuji, Okafuji, Ikuo, Miyoshi, Mari, Onoe, Yasuhiro, Kawano, Yoshifumi, Kinjo, Noriko, Mori, Masaaki, Mozaffarian, Neelufar, Kupper, Hartmut, Santra, Sourav, Patel, Gina, Kawai, Shinichi, Yokota, Shumpei]
通讯作者: Yokota, Shumpei
DOI: 10.1007/s10165-011-0540-6
发表时间: 2012-08-01
期刊: MODERN RHEUMATOLOGY
影响因子: 2.2
作者: [Ozawa, Remi, Inaba, Yutaka, Yokota, Shumpei]
通讯作者: Yokota, Shumpei
Recent Advances in Pediatric Rheumatic Diseases from the Viewpoint of Dysregulation of Proinflammatory Cytokines
从促炎细胞因子失调的角度看小儿风湿性疾病的最新进展
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Ozawa R, Inaba Y, Mori M, Hara R, Kikuchi M, Higuchi R, Miyamae T, Imagawa T, Fujiwara T, Saito T, Yokota S, Ozawa R,Inaba Y,Mori M,Hara R,Kikuchi M,Miyamae T,Imagawa T,Yokota s, Yokota S.]
通讯作者: Yokota S.
Definitive differences inn laboratory and radiological characteristics between two subtypes of juvenile idiopathic arthritis:systemic arthiritis and polyarthritis
幼年特发性关节炎两种亚型:系统性关节炎和多发性关节炎在实验室和放射学特征上的明确差异
DOI: --
发表时间: 2011
期刊: Mod Rheumatol
影响因子: 2.2
作者: [Ozawa R, Inaba Y, Mori M, Hara R, Kikuchi M, Higuchi R, Miyamae T, Imagawa T, Fujiwara T, Saito T, Yokota S, Ozawa R,Inaba Y,Mori M,Hara R,Kikuchi M,Miyamae T,Imagawa T,Yokota s]
通讯作者: Ozawa R,Inaba Y,Mori M,Hara R,Kikuchi M,Miyamae T,Imagawa T,Yokota s
9
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    • 批准号:
      19390287
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $12.23万
    • 财政年份:
      2007
    • 负责人:
      YOKOTA Shumpei
    • 依托单位:
    Exhaustive analysis about juvenile idiopathic arthritis by using an anti-IL-6 receptor antibody
    • 批准号:
      16390305
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.22万
    • 财政年份:
      2004
    • 负责人:
      YOKOTA Shumpei
    • 依托单位:
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    PATHOPHYSIOLOGY OF INTRACRANIAL CYTOKINES IN INFLUENZA-ASSOCIATED ENCEPHALOPATHY
    • 批准号:
      12470169
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $3.9万
    • 财政年份:
      2000
    • 负责人:
      YOKOTA Shumpei
    • 依托单位: