DISEASE-ACTIVITY MARKERS IN EPSTEIN-BARR VIRUS INFECTION AND ESTABLISHMENT OF CELL-LINE POSITIVE FOR EB VIRUS.

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Firstly we established the PCR detection system for EB virus using primers originated from IR1 gene sequences. The detection system was useful, and detected EBV genome in mononuclear cells in peripheral blood, inflammatory cells in pleural effusion, and bone marrow cells. The activated macrophages and lymphocytes were the populations of the exudative cells. The disease activity of chronic active EBV infection and virus-associated hemophagocytic syndrome was monitered well by AST,ALT,LDH,fibrinogen-fibrin degrades (FDP-E,D dimer), and serum ferritin. Cytokines originated from activated macrophages and T cells were abnormally high in these diseases, and the regulatory imbalances of these cytokines may be contributed to generalized vasculitis. Therapy was initiated to stabilize macrophages and T cells by administratiog lipo-dezamethasone and cyclosporin A.