The pathophysiology of EB virus infection, and screening investigational drugs using a new human tissue model

EB 病毒感染的病理生理学，以及利用新的人体组织模型筛选研究药物

• 批准号: 23591564
• 负责人: ITO Yoshinori
• 金额: $ 3.33万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591564/
• 关键词: Epstein-Barr ウイルス; ヒト組織モデル; ラパマイシン; mTOR; 感染細胞; 治療効果; EBウイルス; 感染モデル; 扁桃組織; スクリーニング

Epstein-Barr virus (EBV) causes intractable diseases, including EBV-associated malignancies. Using a new human tissue model, EBV-infected cells were analyzed during the early stage of infection. Naive and memory B cells were found to be infected with EBV. The potential effects of the investigational drugs bortezomib, rapamycin, and mogamulizumab were analyzed using the human tissue model and a murine xenograft model. They showed therapeutic effects in the models.

EB病毒（EBV）引起难治性疾病，包括EBV相关的恶性肿瘤。使用新的人体组织模型，在感染的早期阶段分析EBV感染的细胞。发现初始和记忆B细胞被EBV感染。使用人体组织模型和小鼠异种移植模型分析了研究药物硼替佐米、雷帕霉素和mogamulizumab的潜在作用。在模型中显示出治疗作用。

项目成果

Immunogenicity of inactivated 2009 H1N1 influenza vaccine in pediatric liver transplant recipients

2009 H1N1 流感灭活疫苗对儿童肝移植受者的免疫原性

• DOI: 10.1016/j.vaccine.2011.04.012
• 发表时间: 2011
• 期刊: Vaccine
• 影响因子: 5.5
• 作者: Torii;Y. Kimura;H. Ochi;N. Kaneko;K. Ando;H. Kiuchi;T. Ito;Y.
• 通讯作者: Y.

Hyperferritinemia in Neonatal and Infantile Human Parechovirus-3 Infection in Comparison with Other Infectious Diseases.

与其他传染病相比，新生儿和婴儿人副肠病毒-3 感染中的高铁蛋白血症。

• DOI: 10.1016/j.jiac.2013.11.002
• 发表时间: 2014
• 期刊: Journal of Infection and Chemotherapy
• 影响因子: 2.2
• 作者: Hara S;Kawada J;Kawano Y;Yamashita T;Minagawa H;Okumura N;Ito Y.
• 通讯作者: Ito Y.

Late-onset sensorineural hearing loss due to asymptomatic congenital cytomegalovirus infection retrospectively diagnosed by polymerase chain reaction using preserved umbilical cord.

使用保存的脐带通过聚合酶链反应回顾性诊断无症状先天性巨细胞病毒感染导致的迟发性感音神经性听力损失。

• DOI: 10.1177/0009922810380903
• 发表时间: 2011
• 期刊: Clin Pediatr
• 影响因子: 1.6
• 作者: Ikeno M; et al.
• 通讯作者: et al.

Risk factors for poor outcome in congenital cytomegalovirus infection and neonatal herpes on the basis of a nationwide survey in Japan

• DOI: 10.1111/ped.12122
• 发表时间: 2013-10-01
• 期刊: PEDIATRICS INTERNATIONAL
• 影响因子: 1.4
• 作者: Ito, Yoshinori;Kimura, Hiroshi;Moriuchi, Hiroyuki
• 通讯作者: Moriuchi, Hiroyuki

Epstein Barr-viruses-associated lymphoid malignancies: the expanding spectrum of hematopoietic neoplasms.

EB 病毒相关淋巴恶性肿瘤：造血系统肿瘤的扩展谱。

• 发表时间: 2013
• 期刊: Nagoya J Med Sci
• 影响因子: 0.9
• 作者: Kimura H;Kawada J;Ito Y
• 通讯作者: Ito Y