Evaluation of vascular smooth muscle cell function and response mechanism according to transformation from constitution type to secretion type in acute phase of vasculitis

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I made a vasculitis animal model of the Kawasaki disease resemblance,and elucidated migration of a vascular smooth muscle cell from a media by the destruction of the inner elasticity band with a vasculitis histologically in the subendothelial site.Furthermore, the possibility that the vascular smooth muscle cell which migrated in the subendothelial site was transformed in a secretion type from a constitution type by the expression of transcriptional factors such as KLF5 and Egr-1 was suggested. But enough estimation was not accomplished about the function and response mechanism of a transformed vascular smooth muscle cell.