Study on HHV-6 reactivation mechanism in DIHS, by using GVHD as a disease model

HHV-6再激活在药物诱导超敏反应综合征（DIHS）的发病机制中发挥重要作用。在这项研究中，我们的目的是阐明HHV-6在DIHS中再活化的机制。结果，我们观察到调节性T细胞（Treg）浸润到皮肤病变的时间导致HHV-6再激活从DIHS的发作，和TARC，一种趋化因子参与的Treg的迁移，在急性期，血清TARC水平和HHV-6再激活之间的密切相关性。这些结果表明，TARC本身，或TARC增加后的免疫调节在DIHS中HHV-6再激活中起重要作用的可能性。

HHV-6 reactivation plays an important role in the pathogenesis of drug induced hypersensitivity syndrome(DIHS). In this study, we aimed to elucidate the mechanism of HHV-6 reactivation in DIHS. As a result, we observed infiltration of regulatory T cells (Treg) into the skin lesion in the period leading up to the HHV-6 reactivation from the onset of DIHS, and a marked increase of TARC, a chemokine involved in the migration of Treg, during the acute phase, and a close correlation between serum TARC levels and HHV-6 reactivation. These results suggest the possibility that TARC itself, or the immune modulation following the increase of TARC plays an important role in HHV-6 reactivation in DIHS.