Development of therapeutic agents for Alzheimer's disease focused by a new modulator of gamma-secretase complex

以新型γ-分泌酶复合物调节剂为重点开发阿尔茨海默病治疗剂

• 批准号: 23591705
• 负责人: KATAYAMA Taiichi
• 金额: $ 3.33万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-28 至 2015-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591705/
• 关键词: アルツハイマー病; プレセニリン; ガンマセクレターゼ; アミロイド; 脳・神経; 認知症; ミトコンドリア; γセクレターゼ

项目成果

N-ethylmaleimide-sensitive factor interacts with the serotonin transporter and modulates its trafficking: implications for pathophysiology in autism.

N-乙基马来酰亚胺敏感因子与5-羟色胺转运蛋白相互作用并调节其运输：自闭症中对病理生理学的影响。

• DOI: 10.1186/2040-2392-5-33
• 发表时间: 2014
• 期刊: Molecular autism
• 影响因子: 6.2
• 作者: Iwata K;Matsuzaki H;Tachibana T;Ohno K;Yoshimura S;Takamura H;Yamada K;Matsuzaki S;Nakamura K;Tsuchiya KJ;Matsumoto K;Tsujii M;Sugiyama T;Katayama T;Mori N
• 通讯作者: Mori N

XLMR protein related to neurite extension (Xpn/KIAA2022) regulates cell-cell and cell-matrix adhesion and migration

• DOI: 10.1016/j.neuint.2013.09.011
• 发表时间: 2013-11-01
• 期刊: NEUROCHEMISTRY INTERNATIONAL
• 影响因子: 4.2
• 作者: Magome, Takuya;Hattori, Tsuyoshi;Katayama, Taiichi
• 通讯作者: Katayama, Taiichi

TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression.

• DOI: 10.1371/journal.pone.0051912
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Takamura H;Koyama Y;Matsuzaki S;Yamada K;Hattori T;Miyata S;Takemoto K;Tohyama M;Katayama T
• 通讯作者: Katayama T

Lack of dopaminergic inputs elongates the primary cilia of striatal neurons.

• DOI: 10.1371/journal.pone.0097918
• 发表时间: 2014
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Miyoshi K;Kasahara K;Murakami S;Takeshima M;Kumamoto N;Sato A;Miyazaki I;Matsuzaki S;Sasaoka T;Katayama T;Asanuma M
• 通讯作者: Asanuma M