A study for improvement of pancreatic islet transplantation outcome by using two-layer method and rare sugar

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Islet transplantation is a curative treatment option for Type-1 diabetes. Improving islet function after isolation would result in better clinical outcomes of islet transplantation. In this study, we examined whether addition of D-allose, one of rare sugars, to islet culture medium had a beneficial effect on rat islet viability and function. As results, insulin secretion increased in the group with D-allose in overnight culture compared to the control without D-allose. In addition, diabetic nude mice transplanted islets after co-culture with D-allose demonstrated significantly higher cure rate of diabetes compared to the control. Because a oxidative stress marker (malondialdehyde) of islets was significantly reduced by co-culture with D-allose, this rare sugar possibly has an antioxidative effect.