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Identification of mechanism of hepatocarcinogenesis by analysi of microRNA

Identification of mechanism of hepatocarcinogenesis by analysi of microRNA
通过microRNA分析鉴定肝癌发生机制
批准号：
23591994
负责人：
KUBO Shoji
金额：
$2.33万
依托单位：
Osaka City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011 至 2013
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591994/
关键词：
肝細胞癌がん遺伝子マイクロRNA生活習慣病

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中文摘要
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英文摘要
The mechanism of hepatocarcinogenesis was investigated using microRNA obtained from patients with hepatocellular carcinoma. The expression of 12 miRNA, especially miR-18b expression, varied significantly correlated to degree of histological differentiation. miR-18b can control the expression of trinucleotide repeat containing 6B as a target gene. Over-expression of miR-18b or down-regulation of TNCR6B accelerated cell proliferation and loss of cell adhesion ability. HCC patients with high miR-18b expression had a significantly shorter relapse-free period than those with low expression. miR-18b is a diagnostic and prognostic marker for HCC progression.
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肝癌診療Q&A
肝癌治疗问答
DOI： --
发表时间： 2013
期刊：
影响因子： --
作者： [Fujita N, Miyachi H, Sugimoto R, Moroka R, Tanaka H, Iwasa M, Tomosugi N, Takei Y, 能祖一裕]
通讯作者： 能祖一裕
Clinicopathological Features of Recurrence in Patients After 10-year Disease-free Survival Following Curative Hepatic Resection of Hepatocellular Carcinoma
DOI： 10.1007/s00268-013-1902-3
发表时间： 2013-04-01
期刊： WORLD JOURNAL OF SURGERY
影响因子： 2.6
作者： [Kaibori, Masaki, Kubo, Shoji, Kwon, A-Hon]
通讯作者： Kwon, A-Hon
Mechanism of hepatocarcinogenesis in patients without infection of hepatitis B and C viruses by molecular biological analysis
  • 批准号：
    20591616
  • 项目类别：
    Grant-in-Aid for Scientific Research (C)
  • 资助金额：
    $2.25万
  • 财政年份：
    2008
  • 负责人：
    KUBO Shoji
  • 依托单位：
    Osaka City University
Constitution of a system of microarray CGH analysis for wide-screening and a research for genes responsible for hepatocellular carcinoma
  • 批准号：
    17591431
  • 项目类别：
    Grant-in-Aid for Scientific Research (C)
  • 资助金额：
    $2.1万
  • 财政年份：
    2005
  • 负责人：
    KUBO Shoji
  • 依托单位：
    Osaka City University
Mechanism of hepatocarcinogenesis by mitochondria DNA analysis and its clinical signifianoe
Strategy for hepatocellular carcinoma from the view point of viral status
  • 批准号：
    09671330
  • 项目类别：
    Grant-in-Aid for Scientific Research (C)
  • 资助金额：
    $1.28万
  • 财政年份：
    1997
  • 负责人：
    KUBO Shoji
  • 依托单位：
    Osaka City University Medical School
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