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Strategy for hepatocellular carcinoma from the view point of viral status

从病毒状态角度治疗肝细胞癌的策略

基本信息

批准号：
09671330
负责人：
KUBO Shoji
金额：
$ 1.28万
依托单位：
Osaka City University Medical School
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671330/
关键词：
Hepatocellular carcinoma Liver resection Hepatitis B virus Hepatitis C virus Hepatitis G virus

项目摘要

Serum markers for Hepatitis B and/or C virus were detected in about 97% of patients who underwent liver resection for hepatocellular carcinoma (HCC) in our department. In 1 % of the patients, hepatitic B virus gene was detected in HCC tissue. Hepatitis G virus RNA was detected in sera in 12 of 213 patients. The 12 patients also had serum markers for hepatitis B virus (HBV) or hepatitis C virus (HCV), indicating that the hepatitis G virus has poor association with HCC.The age was younger in patients infected with HBV than in patients infected with HCV.The tumor size was larger in patients infected with HBV than in patients infected with HCV.The amount of HBV sometimes increased after operation, followed by increase in alanine aminotransferase activity, in patients with wild-type HBV and large amount of HBV.In patients infected with HBV, the risk factors for recurrence included low platelet count, wild-type HBV, high viral load, positive surgical margin, and nonantomic resection. In patients infected with HCV, the risk factors included high age, positive serum HCV RNA, high activities of alanine and aspartate aminotransferase, larged tumor size (more than 4cm), multiple tumors, and portal invasion. Interferon therapy after resection of HCC may be useful to prevent recurrence. Extended resection (anatomic resection) is indicated for patients infected with HBV.For patients infected with HCV, not only complete resection of HCC but a1so strategy for HCV are necessary.

在我们科室接受肝细胞癌 (HCC) 肝切除术的患者中，约 97% 检测到乙型肝炎和/或丙型肝炎病毒血清标志物。 1%的患者在HCC组织中检测到乙型肝炎病毒基因。 213 名患者中有 12 名患者的血清中检测到了 G 型肝炎病毒 RNA。 12例患者还存在乙型肝炎病毒（HBV）或丙型肝炎病毒（HCV）血清标志物，表明庚型肝炎病毒与HCC的相关性较差。HBV感染者的年龄比HCV感染者年轻。HBV感染者的肿瘤体积比HCV感染者大。术后HBV含量有时升高，随后丙氨酸升高。转氨酶活性，野生型HBV和大量HBV感染者。在HBV感染者中，复发的危险因素包括血小板计数低、野生型HBV、高病毒载量、手术切缘阳性和非解剖切除。 HCV感染患者的危险因素包括高龄、血清HCV RNA阳性、丙氨酸和天冬氨酸转氨酶活性高、肿瘤体积大（大于4cm）、多发肿瘤以及门脉侵犯。 HCC 切除后的干扰素治疗可能有助于预防复发。乙型肝炎病毒感染患者需要扩大切除（解剖切除）。丙型肝炎病毒感染患者不仅需要完整切除肝癌，还需要针对丙型肝炎病毒采取相应的治疗策略。