The Cardioprotective Effect Of Interleukin-11 in Cardiac Surgery

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<Objective> We sought to evaluate the cardioprotective effect of IL-11 during prolonged hypothermic ischemia and subsequent reperfusion using a rat heart donor model. <Methods> IL-11 was administered intravenously before harvesting the rat heart. The hearts were preserved in cold buffer for 6 hours, and then mounted onto a Langendorff perfusion apparatus for reperfusion using an oxygenated solution containing IL-11. Normal saline was used instead of IL-11 in the control group. Functional recovery of the reperfused heart was observed and measured, and apoptotic cells were counted using the TUNEL staining technique. <Results> Functional recovery was significant after 6 hours of cold ischemia in the IL-11 group. The number of apoptotic cells was also significantly smaller in the IL-11 group. <Conclusion> IL-11 significantly protected the heart in this rat ischemic model. This was associated with the prevention of apoptosis of the cells exposed to the ischemia-reperfusion injury.