Articular cartilage degradation induced by extensive treadmill exercise is greatly exacerbated by estrogen depletion in mice.

小鼠体内雌激素的消耗大大加剧了大量跑步机运动引起的关节软骨退化。

• 批准号: 23592206
• 负责人: JINNO Tetsuya
• 金额: $ 3.24万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592206/
• 关键词: 変形性関節症; 関節軟骨; メカニカルストレス; 卵巣摘除; ovariectomy; treadmill running; osteoarthritis; cartilage; synovitis; 遺伝的背景; 動物モデル; トレッドミル

Osteoarthritis (OA) is considered to be a multifactorial disease with factors such as chronic inflammation, aging, menopause, obesity, genetic background, and mechanical stress. Estrogen depletion by ovariectomy (OVX) is reported to accelerate cartilage degradation in young female mice. Too much mechanical stress on articular cartilage, which may be caused by overweight, joint instability, or over-exercise, is reported to induce several catabolic factors for articular cartilage. These individual data clearly show that all these factors are involved in the pathogenesis of OA, however, orchestrated effects of these factors in OA progression are still unclear. To analyze the crosstalk between estrogen signal and mechanical stress on articular cartilage homeostasis, we analyzed the severity of cartilage damage after treadmill exercise in OVX mice. Here we reported that degree of articular cartilage degeneration induced by extensive treadmill exercise was greatly exacerbated by OVX.

骨关节炎（OA）被认为是一种多因素疾病，其因素包括慢性炎症、衰老、绝经、肥胖、遗传背景和机械应力。据报道，通过卵巢切除术（OVX）消耗雌激素会加速年轻雌性小鼠的软骨退化。关节软骨上过多的机械应力，这可能是由超重，关节不稳定或过度运动引起的，据报道会引起关节软骨的几种分解代谢因子。这些个体数据清楚地表明，所有这些因素都参与了OA的发病机制，然而，这些因素在OA进展中的协同作用仍不清楚。为了分析雌激素信号和机械应力对关节软骨稳态的影响，我们分析了OVX小鼠在跑步机运动后软骨损伤的严重程度。在这里，我们报告了关节软骨退行性变的程度引起广泛的跑台运动大大加剧了OVX。

项目成果

Properties and usefulness of aggregates of synovial mesenchymal stem cells as a source for cartilage regeneration.

• DOI: 10.1186/ar3869
• 发表时间: 2012-06-07
• 期刊: Arthritis research & therapy
• 影响因子: 4.9
• 作者: Suzuki S;Muneta T;Tsuji K;Ichinose S;Makino H;Umezawa A;Sekiya I
• 通讯作者: Sekiya I

Elimination of bmp7 expression from the limb enhances articular cartilage degeneration and synovial hyperplasia in adult mice

消除肢体中的 bmp7 表达会增强成年小鼠的关节软骨退化和滑膜增生

• 发表时间: 2014
• 作者: K. Abula;T. Muneta;K. Miyatake;J. Yamada;Y. Matsukura;M. Inoue;I. Sekiya;D. Graf;A. Economides;V. Rosen;K. Tsuji
• 通讯作者: K. Tsuji

関節内処置を必要としないマウスの膝関節軟骨変 性モデル:卵巣摘出と強制走行の影響

无需关节内治疗的小鼠膝关节软骨退变模型：卵巢切除和强迫跑步的效果

• 发表时间: 2011
• 作者: 中村知樹;松峯昭彦;松原孝夫;淺沼邦洋;渥美覚;内田淳正;須藤啓広.;宮武和正
• 通讯作者: 宮武和正

Mesenchymal stem cells in synovial fluid increase after meniscus injury.

• DOI: 10.1007/s11999-013-3418-4
• 发表时间: 2014-05
• 期刊: Clinical orthopaedics and related research
• 影响因子: 4.2
• 作者: Matsukura Y;Muneta T;Tsuji K;Koga H;Sekiya I
• 通讯作者: Sekiya I

Transplantation of Achilles tendon treated with bone morphogenetic protein 7 promotes meniscus regeneration in a rat model of massive meniscal defect.

• DOI: 10.1002/art.38099
• 发表时间: 2013-11
• 期刊: ARTHRITIS AND RHEUMATISM
• 作者: Ozeki, Nobutake;Muneta, Takeshi;Koga, Hideyuki;Katagiri, Hiroki;Otabe, Koji;Okuno, Makiko;Tsuji, Kunikazu;Kobayashi, Eiji;Matsumoto, Kenji;Saito, Hirohisa;Saito, Tomoyuki;Sekiya, Ichiro
• 通讯作者: Sekiya, Ichiro