Articular cartilage degradation induced by extensive treadmill exercise is greatly exacerbated by estrogen depletion in mice.

骨关节炎（OA）被认为是一种多因素疾病，与慢性炎症、衰老、更年期、肥胖、遗传背景和机械应力等因素有关。据报道，卵巢切除术（OVX）引起的雌激素消耗会加速年轻雌性小鼠的软骨降解。据报道，过重、关节不稳定或过度运动引起的关节软骨承受过多的机械应力会诱发关节软骨的几种分解代谢因子。这些个体数据清楚地表明，所有这些因素都参与了OA的发病机制，然而，这些因素在OA进展中的协同作用仍不清楚。为了分析雌激素信号与机械应力对关节软骨稳态的影响，我们分析了OVX小鼠在跑步机运动后软骨损伤的严重程度。在这里，我们报道了OVX大大加重了广泛的跑步机运动引起的关节软骨退变程度。

Osteoarthritis (OA) is considered to be a multifactorial disease with factors such as chronic inflammation, aging, menopause, obesity, genetic background, and mechanical stress. Estrogen depletion by ovariectomy (OVX) is reported to accelerate cartilage degradation in young female mice. Too much mechanical stress on articular cartilage, which may be caused by overweight, joint instability, or over-exercise, is reported to induce several catabolic factors for articular cartilage. These individual data clearly show that all these factors are involved in the pathogenesis of OA, however, orchestrated effects of these factors in OA progression are still unclear. To analyze the crosstalk between estrogen signal and mechanical stress on articular cartilage homeostasis, we analyzed the severity of cartilage damage after treadmill exercise in OVX mice. Here we reported that degree of articular cartilage degeneration induced by extensive treadmill exercise was greatly exacerbated by OVX.