Toll-like receptors signal-induced bone and cartilage destruction in rheumatoid arthritis

点击翻译按钮获取中文摘要

Immunohistochemical analyses using synovial tissues from patients with rheumatoid arthritis (RA) demonstrated that Toll-like receptor (TLR)-2 and -4 but not TLR-3, -7, -8, -9 were expressed in the RA synovium. Then, correlation between TLR signal-induced oxidative stress (ROM) and clinical parameters associated with RA were analyzed. The mean value of serum ROM in RA and diabetes mellitus (DM) patients was 455.9 and 390.7 U.CARR (normal values <300), respectively, and there was significant differences between the groups (P<0.001). The multivariate analyses concluded that serum ROM values were significantly correlated with CRP and DAS28-ESR among the clinical parameters associated with RA.