Effect of lipid cytokine on arthritis

在类风湿关节炎患者中，肥胖患者的炎症反应相对较低。所以我们认为来自脂肪组织的瘦素可能会减少炎症。首先，ob/ob小鼠体内没有瘦素，没有出现任何由抗胶原抗体引起的关节炎。接下来，我们通过高脂饮食培养获得性瘦素抵抗小鼠。小鼠瘦素浓度升高，抗胶原抗体诱导的关节炎程度降低。最后，我们不能在瘦素转基因小鼠中诱导关节炎，表现为高瘦素血症。最后我们发现瘦素降低了促炎细胞因子IL-6的产生。高瘦素血症可以减轻炎症。

Among rheumatoid arthritis patients, fatty patients show relatively low inflammation. So we thought that leptin derived from fat tissue might reduce the inflammation. At first ob/ob mouse, which has no leptin in the body, did not show any kind of arthritis induced by anti-collagen antibody. Next we created acquired leptin resistance mice by high fat diet. They got higher leptin concentration and showed lower grade of arthritis induced by anti-collagen antibody. At last, we could not induce arthritis in leptin transgenic mice, which showed hyperleptinemia. Finally we found that leptin decreased the production of IL-6, pro-inflammatory cytokine. Hyperleptinemia reduces inflammation.