Insulin preconditioning elevates p-Akt and cardiac contractility after reperfusion in the isolated ischemic rat heart
Insulin preconditioning elevates p-Akt and cardiac contractility after reperfusion in the isolated ischemic rat heart
批准号:
23592280
负责人:
SATO Hiroaki
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
与心脏缺血相关的胰岛素治疗的最佳时机尚不清楚。我们验证了在缺血前给予胰岛素比在缺血后给予胰岛素提供更好的心脏保护的假设。从雄性大鼠分离的心脏采用Langendorff方法制备,并分为三组。在本研究中,我们得出结论,在离体鼠缺血心脏中,在缺血前给予胰岛素比仅在再灌流时给予胰岛素具有更好的心脏保护作用。
英文摘要
The optimal timing of insulin institution related to cardiac ischemia was unclear.We tested the hypothesis that insulin administered prior to ischemia provides better cardioprotection than insulin administration after ischemia.Hearts isolated from male rats were prepared using Langendorff method and divided into three groups.In this study, we concluded insulin administration prior to ischemia provides better cardioprotection than insulin administration only at reperfusion in the isolated ischemic rat heart.
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山梨大学麻酔科学教室心筋代謝研究室
山梨大学麻醉科心脏代谢研究室
DOI:
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发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Effect of Hyperinsulinemic Normoglycemic Clamp on Isolated Rat Heart. American Society of Anesthesiologists (ASA)
高胰岛素正常血糖钳夹对离体大鼠心脏的影响。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[佐藤環, 他]
通讯作者:
他
Preconditioning Effect of High Dose Insulin in Isolated Rat Heart
大剂量胰岛素对离体大鼠心脏的预处理作用
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[福島久史, 佐藤宏明, 佐藤環, 小口健史, 中楯陽介, 松川隆, 小田 裕, 小田 裕, Hisashi Fukushima]
通讯作者:
Hisashi Fukushima
Effect of Hyperinsulinemic Normoglycemic Clamp on Isolated Rat Heart
高胰岛素正常血糖钳夹对大鼠离体心脏的影响
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[佐藤環, 他, 小田 裕, 小田 裕, Tamaki Sato]
通讯作者:
Tamaki Sato
心臓虚血再灌流モデルにおける高用量インスリン先行投与の心筋保護効果
大剂量胰岛素对心肌缺血再灌注模型的心肌保护作用
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[福島久史, 他]
通讯作者:
他
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Eruption mechanisms and crystal textures
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Effects of genetic varitation in host plants on herbivourous insect communities
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