The role of ASICs in neuroprotection after spinal ischemia

ASIC 在脊髓缺血后神经保护中的作用

• 批准号: 23592305
• 负责人: KUSAMA NOBUYOSHI
• 金额: $ 3.33万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592305/
• 关键词: ASIC; 脊髄虚血

Acid-sensing ion channels (ASICs) are sodium channels gated by extracellular protons. ASIC1a channels possess intersubunit Cl-binding sites in the extracellular domain, which are highly conserved between ASIC subunits. We found that anions modulate a variety of ASIC properties and are dependent on the subunit composition, and the mechanism of modulation for ASIC2a and ASIC3 is distinct from that of ASIC1a. We speculate that modulation of ASIC gating by Cl is a novel mechanism to sense shifts in extracellular fluid composition.

酸感离子通道是由细胞外质子门控的钠离子通道。ASIC1a通道在细胞外区域具有亚基间cl结合位点，在ASIC亚基之间高度保守。我们发现阴离子可以调节多种ASIC特性，并且依赖于亚基组成，ASIC2a和ASIC3的调制机制与ASIC1a不同。我们推测Cl对ASIC门控的调节是一种感知细胞外液成分变化的新机制。

项目成果

ASIC2 subunits facilitate expression at the cell surface and confer regulation by PSD-95.

• DOI: 10.1371/journal.pone.0093797
• 发表时间: 2014
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Harding AM;Kusama N;Hattori T;Gautam M;Benson CJ
• 通讯作者: Benson CJ

Acid-sensing ion channels (ASICs) are differentially modulated by anions dependent on their subunit composition.

酸敏感离子通道 (ASIC) 受阴离子的差异调节，具体取决于其亚基组成。

• DOI: 10.1152/ajpcell.00216.2012
• 发表时间: 2013
• 期刊: Am J Physiol Cell Physiol.
• 作者: Kusama N;Gautam M;Harding AM;Snyder PM;Benson CJ.
• 通讯作者: Benson CJ.