Role of mTOR signaling pathway for the growth and proliferation of uterine leiomyoma

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We investigated the role of mammalian target of rapamycin (mTOR) signaling pathway for the growth and proliferation of uterine leimyoma; however, we did not find any overexpression of protein levels as well as mRNA levels of mTOR signaling pathway-related genes in uterine leiomyoma compared with those in myometrial tissues.Next, we established a novel in vivo xenograft model for uterine leiomyoma, and evaluated its characters. The non-obese diabetic/severe combined immunodeficient murine xenograft model has shown a sex-steroid dependent growth of xenograft beneath the kidney capsule, a positive expression for both estrogen and progesterone receptors, and a similar representative gene expression compared with original leiomyoma tissue. In this model, we use only non-genetic manupilated primary cultured leiomyoma cells; therefore, we believe this model is a good tool for the research and the development of new therapies for uterine leiomyoma.