Nuclear matrix associating factors, Satb, are novel regulators of murine placentation

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We identified novel regulators of trophoblast cell differentiation, Satb1 and Satb2. They had been known as nuclear matrix associating molecules. Satb1 and Satb2 are necessary to maintain rodent trophoblast cells at stem cell condition. We also discovered Eomes as a target gene of Satb1 and Satb2. Eomes is a well-known regulator necessary for maintenance of trophoblast stem cells. Therefore, Satb1 and Satb2 upregulate Eomes expression to keep trophoblast cells from differentiation. We published these results as a paper (Asanoma et al., 2012).