Evaluation of an extracellular matrix protein fibulin-1 in pathophysiology of human endometrial function

子宫内膜妊娠是子宫内膜妊娠建立和维持的关键因素。培养3天后，孕酮刺激的人子宫内膜间质细胞中fibulin-1 mRNA水平显著增加。这些结果表明，fibulin-1是一个重要的分子，介导孕激素的作用，在人类子宫内膜分化向种植。不孕症患者子宫内膜中fibulin-1 mRNA水平显著降低。我们的研究结果不仅有助于深入了解关键生殖过程的机制，如蜕膜化和早期妊娠的建立和维持，而且对未来的临床应用植入失败。

Progesterone is a key factor in establishment and maintenance of pregnancy in the human endometrium. The fibulin-1 mRNA levels were significantly increased in human endometrial stromal cells stimulated with progesterone after 3 days of culture. These results suggest that fibulin-1 is an important molecule that mediates progesterone action in human endometrial differentiation towards implantation. The levels of fibulin-1 mRNA were significantly decreased in the endometrium of infertile patients. Our findings contribute not only on the insight into mechanisms of key reproductive processes such as decidualization and the establishment and maintenance of early pregnancy, but also on future clinical applications for implantation failure.