Antidepressant and vestibular plasticity

我们研究了慢性应用抗抑郁药对豚鼠前庭系统的影响。在海马区，观察到磷酸化的creb样免疫反应，而在前庭系统，未发现免疫反应。我们评估了BDNF mRNA。在海马区，而不是前庭系统，抗抑郁组BDNF mRNA水平显著高于非抗抑郁组。右外侧半规管横断24小时后，我们检测前庭系统BDNF和trkB mRNA。在前庭神经节细胞中，抗抑郁药组损伤侧BDNF mRNA和trkB mRNA水平均高于非抗抑郁药组完好侧。在前庭核中，抗抑郁组损伤侧BDNF mRNA水平显著高于非抗抑郁组完好侧。

We investigated the effects of chronic application of antidepressant on the vestibular system in guinea pigs. In the hippocampal region, phosphorylated CREB-like immunoreactivities were observed, while, in the vestibular system, no immunoreactivities were found. We evaluated BDNF mRNA. In the hippocampal region, not in the vestibular system, BDNF mRNA level was statistically higher in the antidepressant group than that in the non-antidepressant group. Twenty-four hours after right lateral semicircular canal transection, we investigated BDNF and trkB mRNA in the vestibular system. In the vestibular ganglion cells, BDNF mRNA and trkB mRNA levels of the lesioned side in the antidepressant group were statistically higher than that of the intact side in the non-antidepressant group. In the vestibular nuclei, BDNF mRNA level of the lesioned side in the antidepressant group was statistically higher than that of the intact side in the non-antidepressant group.