Vestibular plasticity-a role of vestibular ganglion-

我评估了各种前庭疾病后，p-CREB在豚鼠前庭神经节细胞中的诱导模式。在每个模型中，p-CREB在紊乱后8小时内消失。基于这一事实，我发现内耳直接注入抗抑郁药罗利普兰可以诱导前庭神经节细胞中p-CREB的上调。同时，罗利普兰对前庭神经节细胞也有一定的损伤作用。其次，系统应用三环类抗抑郁药阿米替林治疗豚鼠前庭功能障碍，促进前庭功能恢复。

I evaluated patterns of p-CREB induction in guinea pig vestibular ganglion cells after various kinds of vestibular disorders. In each model, p-CREB had disappeared within 8 hours after disorder. On the basis of this fact, I found that direct inner ear infusion of rolipram, one of antidepressants, induced p-CREB up-regulation in vestibular ganglion cells. While, rolipram also induced some damage on vestibular ganglion cells morphologically. Next, amitriptyline, a tricyclic antidepressant, was applied systemically to guinea pig with vestibular disorder, and facilitated vestibular functional recovery.