In Vivo and In Vitro Feasibility Studies of Intraocular Use of FocalSeal to Close Retinal Breaks

眼内使用 FocalSeal 闭合视网膜裂孔的体内和体外可行性研究

• 批准号: 23592551
• 负责人: OKAMOTO Fumiki
• 金额: $ 3.24万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592551/
• 关键词: 網膜剥離; シーラント; focalseal; 硝子体手術; 眼科; 網膜; 組織シーラント

FocalSeal (FS) is an absorbable polyethylene glycol-based synthetic hydrogel sealant. This liquid is polymerized under visible xenon illumination, and forms clear, flexible, and firmly adherent hydrogel. In this study, we evaluated the intraocular biocompatibility of the sealant and explored its efficacy for closing retinal breaks, and evaluated the ability of FS to close sclerotomies of microincision vitrectomy.Dutch pigmented normal rabbits and enucleated porcine eyes were used in this study. Adhesion of FS to the retina was relatively strong. The pH of BSS containing FS was between 7.2 to 8.0. No inflammatory reaction was observed in the eyes by ophthalmic and histological examination. There was no significant difference in the ERG between the study and control groups. FS appeared to effectively seal retinal breaks in our in vitro experiment, and the in vivo studies indicated that FS was not toxic to the eye.

FocalSeal（FS）是一种可吸收的聚乙二醇基合成水凝胶密封剂。该液体在可见氙照明下聚合，并形成透明、柔性和牢固粘附的水凝胶。在本研究中，我们评价了密封剂的眼内生物相容性，并探讨了其关闭视网膜裂孔的有效性，并评价了FS关闭微切口玻璃体切除术的巩膜切口的能力。FS与视网膜的粘附力较强。含有FS的BSS的pH在7.2至8.0之间。眼部及组织学检查未见炎性反应。实验组和对照组的ERG无显著性差异。在我们的体外实验中，FS似乎可以有效地封闭视网膜裂孔，体内研究表明FS对眼睛没有毒性。

项目成果

小切開硝子体手術における強膜創閉鎖剤としてのFocalSealの応用

FocalSeal作为巩膜伤口闭合剂在小切口玻璃体切割手术中的应用

• 发表时间: 2013
• 作者: 岡本史樹;星崇仁;福田慎一;加治優一;新井三樹;広瀬竜夫;大鹿哲郎
• 通讯作者: 大鹿哲郎

In Vivo and In Vitro Feasibility Studies of Intraocular Use of FocalSeal to Close Retinal Breaks in Porcine and Rabbit Eyes

眼内使用 FocalSeal 闭合猪和兔眼视网膜裂孔的体内和体外可行性研究

• 发表时间: 2014
• 作者: Sujin Hoshi;Fumiki Okamoto;Yuichi Kaji;Mikki Arai;Tatsuo Hirose;Tetsuro Oshika
• 通讯作者: Tetsuro Oshika

FocalSeal for Closure of Sutureless Sclerotomies of Vitrectomy : An In Vivo and Histological Study

用于闭合玻璃体切除术无缝线巩膜切开术的 FocalSeal：体内和组织学研究

• 发表时间: 2014
• 作者: Shoko ishida;Fumiki Okamoto;Sujin Hoshi;Shinichi Fukuda;Yoshimi Sugiura;Mikki Arai;Tetsuro Oshika
• 通讯作者: Tetsuro Oshika

FocalSealの網膜裂孔閉鎖に対する有用性と網膜毒性の評価

评估 FocalSeal 用于视网膜撕裂闭合的有效性和视网膜毒性

• 发表时间: 2013
• 作者: 星崇仁;岡本史樹;杉浦好美;加治優一;新井三樹;広瀬竜夫;大鹿哲郎
• 通讯作者: 大鹿哲郎