The mechanism of adipose-derived stem cells on wound healing and less scarring

脂肪干细胞促进伤口愈合和减少疤痕的机制

• 批准号: 23592655
• 负责人: MIZUNO HIROSHI
• 金额: $ 3.24万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592655/
• 关键词: 再生医学; 幹細胞; 創傷治癒; アポトーシス

Previous researches have demonstrated that adipose-derived stem cells (ASCs) possess the potential for not only tissue regeneration but also acceleration of wound healing with less scarring. However, the mechanisms of scar reduction remain still elusive. Therefore, we investigated the detail mechanism including angiogenesis and apoptotic effect of myofibroblasts/fibroblasts using murine diabetic would model. Results showed that epithelization rates, capillary density and the indices of myofibroblast apoptosis, and fibroblast apoptosis were all higher in ASCs group than in the control group mainly within 2 weeks after injury. These findings suggest that ASCs accelerate skin would healing at the same time as inducing apoptosis of both myofibroblasts and fibroblasts, thereby reducing scar formation in a diabetic murine model.

以往的研究表明，脂肪源性干细胞（ASCs）不仅具有组织再生的潜力，而且具有加速伤口愈合和减少瘢痕形成的潜力。 然而，疤痕减少的机制仍然难以捉摸。 因此，我们利用小鼠糖尿病模型研究了肌成纤维细胞/成纤维细胞的血管生成和凋亡作用的详细机制。 结果显示，ASCs组的上皮化率、毛细血管密度、肌成纤维细胞凋亡指数、成纤维细胞凋亡指数均高于对照组，主要集中在伤后2周内。 这些发现表明ASC在诱导肌成纤维细胞和成纤维细胞凋亡的同时加速皮肤愈合，从而减少糖尿病小鼠模型中的瘢痕形成。

项目成果

Therapeutic strategies for wound healing by regenerative medicine

再生医学伤口愈合的治疗策略

• 发表时间: 2012
• 作者: Mizuno H;Tanaka R;Matsumoto S;Orbay H;Hyakusoku H;Miyamoto M and Tabata Y
• 通讯作者: Miyamoto M and Tabata Y

Adipose-derived stem cells for skin regeneration 2^<nd> Lübeck

用于皮肤再生的脂肪干细胞 2^<nd> 吕贝克

• 发表时间: 2011
• 作者: F;Nakatani T;Iwase M;Maeda Y;Murao Y;Suzuki Y;Fukushima M;Ide C;Ichioka S;Mizuno H
• 通讯作者: Mizuno H

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Orbay H and Mizuno H Adipose-derived stem cells: current findings and future perspectives

Orbay H 和 Mizuno H 脂肪干细胞：当前发现和未来前景

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