Neuroanatomical investigation of orofacial dysfunctions derived from brain ischmia in rats.

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In this study, we investigated influence of the brain ischemia to the mastication and swallowing. At first, we examined the distribution of orofacial areas of the brain (secondary somatosensory cortex (S2) ) projecting to the trigeminal principal nucleus or oral subnucleus of the trigeminal sensory nuclear complex (TSNC) after injections of a retrograde neural tracer in the normal rats. The results suggest that the orofacial S2 projects selectively to certain rostrocaudal levels of the contralateral TSNC, and the projections may allow the orofacial S2 to accurately modulate orofacial somatosensory transmission to higher brain centers including the orofacial S2 itself (Haque, et al., 2012). If these brain areas are injured, orofacial dysfunction may be occurred. Then we tried to produce the model rat with brain ischemia in orofacial S2 area. However, it is not so easy to make brain ischemia at restricted area. Further investigation should be needed.