Possibility of bone substitute by using tissue engineering, concerning the bone grafting operation to the alveolar cleft of CL/CP.
Possibility of bone substitute by using tissue engineering, concerning the bone grafting operation to the alveolar cleft of CL/CP.
批准号:
23592942
负责人:
YAMAZAKI Yasuharu
金额:
$3.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
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英文摘要
Bone formation of Mesenchymal stromal cells(MSCs) derived from a surplus of maxillary bone fragments, in primary cleft lip / palate operation, was confirmed in vivo. When cultured with serum-free medium, maxilla-derived MSCs exhibited osteogenic potential in both in vitro and in vivo. With bone tissue-derived MSCs cryopreserved more than 10 years, in the safety assessment, no abnormality was found in G-band patterns as a morphologic investigation and in myc or p53 analysis. Moreover osteogenic potential and multipotency were maintained. Cryopreserved bone tissue-derived MSCs may be clinically useful.
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DOI:
10.1016/j.joms.2012.03.021
发表时间:
2012-08
期刊:
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
影响因子:
--
作者:
[A. Takeda;Y. Yamazaki;K. Baba;M. Ishiguro;Kazuya Aoyagi;Shigehiro Ikemoto;E. Uchinuma]
通讯作者:
A. Takeda;Y. Yamazaki;K. Baba;M. Ishiguro;Kazuya Aoyagi;Shigehiro Ikemoto;E. Uchinuma
長期凍結保存された骨組織由来間葉系細胞の骨形成能は代替骨として臨床応用可能である
长期冻存骨组织来源的间充质细胞具有成骨能力,可作为骨替代品应用于临床
DOI:
--
发表时间:
2014
期刊:
影响因子:
--
作者:
[Nakayama E, Kawazu T, Okamura K, Yoshiura K, 杉本孝之,熊澤憲一,山崎安晴,曽根由美子,武田啓,内沼栄樹]
通讯作者:
杉本孝之,熊澤憲一,山崎安晴,曽根由美子,武田啓,内沼栄樹
長期凍結保存された骨組織由来間葉系細胞の骨形成能は代替骨として臨床応用可能である.
长期冷冻保存的骨组织源性间充质细胞的成骨能力可作为骨替代品应用于临床。
DOI:
--
发表时间:
2014
期刊:
影响因子:
--
作者:
[Nakayama E, Kawazu T, Okamura K, Yoshiura K, 杉本孝之,熊澤憲一,山崎安晴,曽根由美子,武田啓,内沼栄樹, 杉本孝之, 山崎安晴 他]
通讯作者:
杉本孝之, 山崎安晴 他
Cord Blood: Banks and Banking, Ethical Issues and Risks/Benefits.
脐带血:银行和银行业务、道德问题和风险/收益。
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Kyoko Baba, Yasuharu Yamazaki, Akira Takeda, Eiju Uchinuma]
通讯作者:
Eiju Uchinuma
Osteogenic Potential, Multipotency, and Cytogenetic safety of human bone tissue-derived mesenchymal stromal cells (hBT-MSCs) after long-term cryopreservation.
长期冷冻保存后人骨组织来源的间充质基质细胞(hBT-MSC)的成骨潜力、多能性和细胞遗传学安全性。
DOI:
--
发表时间:
2014
期刊:
The Kitasato Medical Journal
影响因子:
--
作者:
[Kumazawa K, Sugimoto T, Yamazaki Y, Takeda A, Uchinuma E]
通讯作者:
Uchinuma E
共 25 条
The cryopreservation of umbilical cord blood derived mesenchymal stem cells and the possibility of clinical application of those cells to cleft lip and palate patient.
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批准号:20592345
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2008
-
负责人:YAMAZAKI Yasuharu
-
依托单位:
Quality and safety of cryopreserved human mesenchymal stem cell(MSC) during serial subculture
-
批准号:18592198
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.49万
-
财政年份:2006
-
负责人:YAMAZAKI Yasuharu
-
依托单位:
Development of a hybrid bone substitute with cryopreserved auto stem cell (human bone marrow derived mesenchymal stem cell)
-
批准号:16592018
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.92万
-
财政年份:2004
-
负责人:YAMAZAKI Yasuharu
-
依托单位:
Biological viability of the bone marrow stem cell cultured from bone disease patients
-
批准号:12671961
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.11万
-
财政年份:2000
-
负责人:YAMAZAKI Yasuharu
-
依托单位:
Epidemiological study and candidate gene analysis of cleft lip and /or plate in Japanese patients
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批准号:10671903
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.73万
-
财政年份:1998
-
负责人:YAMAZAKI Yasuharu
-
依托单位:
The Development of Bone Substitute Added with Bone Morphogenetic Protein and Clinical Application
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批准号:01870086
-
项目类别:Grant-in-Aid for Developmental Scientific Research (B).
-
资助金额:$1.92万
-
财政年份:1989
-
负责人:YAMAZAKI Yasuharu
-
依托单位:
海外基金