New therapy for malignant salivary gland tumor by targeting the hormone receptor

针对激素受体的恶性唾液腺肿瘤新疗法

• 批准号: 23592965
• 负责人: SUMIDA TOMOKI
• 金额: $ 3.33万
• 依托单位: Kyushu University (2013)Ehime University (2011-2012)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592965/
• 关键词: 唾液腺腫瘍; ホルモンレセプター; (1)唾液腺腫瘍; ホルモン

Progesterone (Pg) is intimately involved in the development of the mammary gland. Further, it is believed that Pg plays a role in breast cancer progression. However, little is known regarding its role in SGTs. In this study, we used ACCM, a human adenoid cystic carcinoma cell line established from the salivary gland, in order to clarify the role of the progesterone receptor (PR) on cell proliferation. No effect of Pg on cell proliferation was observed in the PR-deficient aggressive ACCM cells. However, after introducing PR into the ACCM cells, Pg markedly inhibited the proliferative activity of the cells. This inhibitory effect on cell proliferation was accompanied by p21 upregulation and Id1, c-myc downregulation. Moreover, Pg-treated PR transfectants showed significant morphological change. Our results suggested that PR reintroduction therapy might be a viable method of inhibiting human SGT progression.

孕激素（Pg）与乳腺的发育密切相关。此外，据信Pg在乳腺癌进展中起作用。然而，关于它在SGT中的作用知之甚少。在这项研究中，我们使用ACCM，从唾液腺建立的人腺样囊性癌细胞系，以阐明孕激素受体（PR）对细胞增殖的作用。在PR缺陷的侵袭性ACCM细胞中，没有观察到Pg对细胞增殖的影响。然而，PR导入ACCM细胞后，Pg显著抑制细胞的增殖活性。这种对细胞增殖的抑制作用伴随着p21上调和Id 1、c-myc下调。此外，PG处理的PR转染子表现出显着的形态学变化。我们的研究结果表明，PR再引入疗法可能是一种抑制人类SGT进展的可行方法。

项目成果

The hormonal therapy for salivary gland tumor～The similarity with Breast cancer

唾液腺肿瘤的激素疗法～与乳腺癌的相似之处

• 发表时间: 2011
• 作者: Nakagawa Y*;Nakayama H*;Nagata M;Yoshida R;Kawahara K;Hirosue A;Tanaka T;Yuno A;Matsuoka Y;Kojima T;Yoshitake Y;Hiraki A;and Shinohara M. (* Contributed equally);Tomoki Sumida
• 通讯作者: Tomoki Sumida

Novel therapeutic strategies for malignant salivary gland tumors: lessons learned from breast cancer.

• DOI: 10.1155/2011/187623
• 发表时间: 2011
• 期刊: International journal of otolaryngology
• 作者: Murase R;Sumida T;Ishikawa A;Murase R;McAllister SD;Hamakawa H;Desprez PY
• 通讯作者: Desprez PY