A study on optimum orthodontic force using periodontal ligament fibroblasts on 3D culture system with aging

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The physiological hypofunction of periodontal ligament (PDL) fibroblasts were considered to be progressing with age. In this investigation, an attempt was made to determine the optimal orthodontic force according to the change of expression of cytokines related to the osteoclasts differentiation after each compressive load on PDL fibroblasts on 3D culture system with aging.From these results, though the difference of 8-OHdG which is an indicator of aging was not observed,the relative amounts of the mRNA expression of cytokines were similar to the expression tendencies between the time of other compressions and the time of 1/4 compression, but there was a higher tendency at the time of 1/4 compression. It has been suggested that when mechanical compression is added to PDL fibroblasts in an experimental system that is assumed as in vivo, and we believe it is effective to move teeth in orthodontic treatment when the tooth was pushed by a distance of a quarter of the width of PDL.