Ultra-high speed x-ray movie recording of mandibular movements

超高速X射线电影记录下颌运动

• 批准号: 23593021
• 负责人: ZEREDO Jorge
• 金额: $ 3.41万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23593021/
• 关键词: 姿勢; 顎運動; 放射線; 低重力; マウス; X線ムービー; 嚥下; 咀嚼; ラット; X線動画映像; 非侵襲モニタリング; 下顎運動; 抗重力反射; X線撮像; 咀嚼運動; 生体信号

This Kakenhi project allowed us to build a device for the study of jaw movements in the mouse through a high-definition x-ray movie system. The use of cineradiographic technology enabled us to study detailed jaw movements in the mouse in a detailed and minimally invasive fashion. In this study, we analyzed postural changes in animals exposed to gravity deceleration. Mice were exposed to partial-gravity deceleration by parabolic flights. As a result, gravity deceleration produced coordinated and generalized extension of head, jaw, spine, and hindlimbs. Joint angles in partial gravity widened about 30% or more in relation to the average 1 g posture. Reflex jaw-opening was observed during gravity deceleration. The magnitude of postural responses was associated positively with gravity deceleration. These results suggest that adaptability to partial gravity may be not only dependent on the partial-gravity level, but also on the rate of gravity change into any given partial-gravity level.

这个Kakenhi项目使我们能够建立一个通过高清X射线电影系统研究老鼠下颌运动的设备。使用放射性电影摄影技术使我们能够详细和微创的方式研究小鼠下颌运动的细节。在这项研究中，我们分析了暴露于重力减速的动物的姿势变化。小鼠通过抛物线飞行暴露于部分重力减速。结果，重力减速使头部、下颌、脊柱和后肢协调和普遍伸展。关节角度在部分重力扩大约30%或更多的平均1 g的姿势。在重力减速过程中观察到反射性下颌张开。姿势反应的幅度与重力减速呈正相关。这些结果表明，对局部重力的适应性可能不仅取决于局部重力水平，而且还取决于重力变化到任何特定局部重力水平的速度。

项目成果

Noninvasive monitoring of rodent muscle/skeletal and visceral movement by X-ray photo imaging in low gravity

低重力下 X 射线照片成像无创监测啮齿动物肌肉/骨骼和内脏运动

• 发表时间: 2012
• 作者: Yasuhiro Kumei;Katsuya Hasegawa;Jorge Zerredo
• 通讯作者: Jorge Zerredo