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Elucidation of the effects of periodontal pathogenic factor and excessive mechanical stress on signaling pathway of orthodontic tooth movement

阐明牙周致病因素和过度机械应力对正畸牙齿移动信号通路的影响

基本信息

批准号：
23593037
负责人：
MAEDA AYA
金额：
$ 3.24万
依托单位：
Kagoshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2011
资助国家：
日本
起止时间：
2011 至 2013
项目状态：
已结题

项目摘要

We found that the constitutive expression of IL-1beta is essential for the induced expression for MIP-2 and MCP-1 in osteoblasts by mechanical stresses in a manner dependent on MyD88, an adaptor molecule for IL-1 receptor and TLRs. Thus, it is suggested that MyD88 signaling pathway is involved in bone remodeling in the early phase of orthodontic treatment. Our findings also indicated that high level concentrations of IL-1beta may promote inflammatory responses of osteoblasts induced by mechanical stress. In the clinical research, it was found that the dental root length was related to the loss of occlusal contact. Additionally, some of the poor bone bridges were improved by orthodontic tooth movement in the early phase after bone graft. These results suggested that the functional stress by occlusal force and mechanical stress may promote root-length formation and bone remodeling.

我们发现，IL-1 β的组成型表达是必不可少的诱导表达MIP-2和MCP-1在成骨细胞的机械应力的方式依赖于MyD 88，IL-1受体和TLR的衔接分子。提示MyD 88信号通路参与了正畸治疗早期的骨重建过程。高浓度的IL-1 β可促进机械应力诱导的成骨细胞炎症反应。临床研究发现，牙根长度与咬合接触丧失有关。此外，部分不良骨桥在植骨后的早期阶段通过正畸牙齿移动得到改善。结果提示，咬合力和机械应力所产生的功能应力可能促进牙根长度的形成和骨改建。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

片側性唇口蓋裂患者の骨移植と歯科矯正治療後の骨架橋と切歯の評価

单侧唇腭裂患者植骨和正畸治疗后骨桥和门牙的评估。

DOI：
发表时间：
2012
期刊：
影响因子：
0
作者：
簡野瑞誠;小野卓史.;前田綾,上原沢子,菅真有,西原一秀,中村典史,宮脇正一
通讯作者：
前田綾,上原沢子,菅真有,西原一秀,中村典史,宮脇正一

Association of CiaRH with resistance of Streptococcus mutans to antimicrobial peptides in biofilms.

DOI：
10.1111/j.2041-1014.2012.00637.x
发表时间：
2012-04
期刊：
Molecular oral microbiology
影响因子：
3.7
作者：
Y. Mazda;M. Kawada-Matsuo;K. Kanbara;Y. Oogai;Y. Shibata;Y. Yamashita;S. Miyawaki;H. Komatsuzawa
通讯作者：
Y. Mazda;M. Kawada-Matsuo;K. Kanbara;Y. Oogai;Y. Shibata;Y. Yamashita;S. Miyawaki;H. Komatsuzawa

Changes in Grafted Autogenous Bone during Edgewise Treatment in Patients with Unilateral Cleft lip/palate or Alveolus

单侧唇/腭裂或牙槽患者Edgewise治疗期间移植自体骨的变化