Molecular genetic study of the specific tooth agenesis in the third molar of EL mice

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A detailed study using Real time PCR, in situ hybridization, immunohistological analysis and DNA microarray revealed that the absence of third molars in EL/sea mice is strongly controlled by the interaction between beta 1 integrin and laminin alpha 5. These results suggest that Apoptosis and Hedgehog pathways are associated with the development of the tooth germs of M3 in the bud stage of EL mice.We concluded that the specific tooth agenesis in EL/sea mice is regulated by the basement membrane proteins such as beta 1 integrin and laminin alpha 5.