Examination of the effects of periodontitis on aging, and development of novel periodontal treatments

检查牙周炎对衰老的影响以及新型牙周治疗方法的开发

• 批准号: 23593069
• 负责人: NAGASAWA Toshiyuki
• 金额: $ 3.33万
• 依托单位: Health Sciences University of Hokkaido
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23593069/
• 关键词: Klotho; 老化; 歯周炎; IL-6; gingival fibroblast; 歯周病; 糖尿病; FOXO; HbA1c; Diabetes; Periodontitis; Insulin

The purpose of this study was to examine the effects of periodontitis on aging. Periodontitis patients with type 2 diabetes were examined to evaluate the association between inflammation and vascular aging. Periodontal tissue of Klotho mouse was examined to evaluate the association between accelerated aging and periodontitis. Results suggested that inflammation might enhance atherosclerosis through the rapid fluctuation of blood sugar. In addition, gingival fibroblasts from Klotho mouse had reduced growth rate, but enhanced inflammatory responses. These results suggest that periodontitis might affect aging through the systemic inflammation.

本研究的目的是探讨牙周炎对衰老的影响。对伴有2型糖尿病的牙周炎患者进行检查，以评估炎症与血管老化之间的关系。对Klotho小鼠牙周组织进行了检查，以评估加速衰老与牙周炎之间的关系。结果表明，炎症可能通过血糖的快速波动促进动脉粥样硬化。此外，Klotho小鼠的牙龈成纤维细胞生长速率降低，但炎症反应增强。提示牙周炎可能通过全身炎症影响衰老。

项目成果

糖尿病・肥満患者における口腔に関する多施設疫学研究

糖尿病及肥胖患者口腔多中心流行病学研究

• 发表时间: 2012
• 作者: 新田浩;片桐さやか;長澤敏行;和泉雄一;金沢真雄;松尾朗;千葉博茂;宮崎滋;宮内孝;大迫文重;金村成智;福井道明;中村直登;安藤雄一;花田信宏;井上修二
• 通讯作者: 井上修二

Effect of glycemic control on periodontitis in type 2 diabetic patients with periodontal disease.

• DOI: 10.1111/jdi.12026
• 发表时间: 2013-05
• 期刊: Journal of diabetes investigation
• 影响因子: 3.2
• 作者: Katagiri S;Nitta H;Nagasawa T;Izumi Y;Kanazawa M;Matsuo A;Chiba H;Fukui M;Nakamura N;Oseko F;Kanamura N;Inagaki K;Noguchi T;Naruse K;Matsubara T;Miyazaki S;Miyauchi T;Ando Y;Hanada N;Inoue S
• 通讯作者: Inoue S

JP-2 type Aggregatibacter actinomycetemcomitans characterization in Japanese periodontitis patients

日本牙周炎患者中 JP-2 型放线菌伴生菌特征分析

• 发表时间: 2012
• 作者: Nagasawa T;Kato S;Shimizu S;Hidaka T;Kado T;Mori M;Furuichi Y
• 通讯作者: Furuichi Y

Expression of CD14, CD16 and CD45 on monocytes from aggressive periodontitis patients Europerio 7

侵袭性牙周炎患者Europerio 7单核细胞CD14、CD16和CD45的表达

• 发表时间: 2012
• 作者: Bharti P;Katagiri S;Ye C;Kobayashi H;Takeuchi Y;Nagasawa T and Izumi Y
• 通讯作者: Nagasawa T and Izumi Y

The anti-phospholipid antibody-dependent and independent effects of periodontopathic bacteria on threatened preterm labor and preterm birth

• DOI: 10.1007/s00404-013-2741-z
• 发表时间: 2013-02
• 期刊: Archives of Gynecology and Obstetrics
• 影响因子: 2.6
• 作者: C. Ye;Sayaka Katagiri;N. Miyasaka;Pariksha Bharti;H. Kobayashi;Y. Takeuchi;Yoshihito Momohara;M. Sekiguchi;Satoko Takamine;T. Nagasawa;Y. Izumi