Examination of the effects of periodontitis on aging, and development of novel periodontal treatments

本研究的目的是探讨牙周炎对衰老的影响。对伴有2型糖尿病的牙周炎患者进行检查，以评估炎症与血管老化之间的关系。对Klotho小鼠牙周组织进行了检查，以评估加速衰老与牙周炎之间的关系。结果表明，炎症可能通过血糖的快速波动促进动脉粥样硬化。此外，Klotho小鼠的牙龈成纤维细胞生长速率降低，但炎症反应增强。提示牙周炎可能通过全身炎症影响衰老。

The purpose of this study was to examine the effects of periodontitis on aging. Periodontitis patients with type 2 diabetes were examined to evaluate the association between inflammation and vascular aging. Periodontal tissue of Klotho mouse was examined to evaluate the association between accelerated aging and periodontitis. Results suggested that inflammation might enhance atherosclerosis through the rapid fluctuation of blood sugar. In addition, gingival fibroblasts from Klotho mouse had reduced growth rate, but enhanced inflammatory responses. These results suggest that periodontitis might affect aging through the systemic inflammation.