Development of visualization of soft tissue morphology and protein concentration by X-ray phase-contrast computed tomography.

通过 X 射线相衬计算机断层扫描开发软组织形态和蛋白质浓度可视化。

• 批准号: 23650277
• 负责人: MOHRI Satoshi
• 金额: $ 2.41万
• 依托单位: Kawasaki Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23650277/
• 关键词: 位相差 CT; X 線; タンパク濃度; X線位相差CT; 濃度勾配; 水晶体; 心臓; 可視化; 国際情報交流（英国）

Clinical X-ray computed tomography (CT) is based on the absorption of X-rays as they pass through the different parts of a patient's body. In this study, we developed phase-contrast X-ray CT that enables to visualize the fine texture of soft tissues that include similar X-ray absorbance materials. Moreover, we could firstly evaluate the concentration gradient of lens protein that enables to correct for spherical aberration. This method may provide new information about vital function.

临床x射线计算机断层扫描（CT）是基于x射线通过患者身体不同部位时的吸收。在这项研究中，我们开发了相衬x射线CT，使包括类似x射线吸光度材料的软组织的精细纹理可视化。此外，我们可以首先评估能够校正球差的透镜蛋白浓度梯度。这种方法可以提供关于生命功能的新信息。

项目成果

Optical properties of in situ eye lenses measured with X-ray Talbot interferometry: a novel measure of growth processes.

• DOI: 10.1371/journal.pone.0025140
• 发表时间: 2011
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Hoshino M;Uesugi K;Yagi N;Mohri S;Regini J;Pierscionek B
• 通讯作者: Pierscionek B