Regulation of RNA Splicing by BNA Antisense Oligonucleotides

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First, we established cell lines containing the reporter gene forantisense oligonucleotides that modify the RNA splicing. Next, we designed and analyzed various BNA antisense oligonucleotides using these screening cell lines, which allowed us to obtain several antisense oligonucleotides that induce exon skipping. We also identified three regions in the dystrophin gene as a good target for antisense oligonucleotide-mediated exon skipping.