Construction of enzyme modelsreducing carbon dioxide

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Formate dehydrogenase, which reduces carbon dioxide, is one of tungsto- and molybdoenzymes. These enzymes contain unique dithiolene moieties called molybdopterin cofactor. In this work, toluene-soluble model complexes having super-bulky substituents and NH・・・S hydrogen bonds weresynthesized. The active molybdenum site was stabilized by hydrophobic surroundings even in aqueous micellar solution. The model complex successfully reduced substrates which are hardly reducible by known models.