Research of hepatocyte transplantation for injured liver and surgical stress .

近年来，非病毒性肝炎和肝硬化的肝细胞癌的外科治疗应得到重视。 我们尝试将肝细胞移植作为肝脏替代疗法应用于临床。 为了实现这一目标，我们建立了模拟临床人类NASH/NAFLD的大鼠肝脏替代模型。 在该模型中，我们揭示了产生胆管谱系细胞的移植细胞的细胞生理学。 此外，我们成功地提高了NASH肝硬化模型的存活率。 在临床研究中，我们报道了供体细胞获取的益处和缺点。 我们还揭示了BTR、ATIII和GSA的临床价值。 我们使用聚类分析对各种肝功能指标进行分类。

In recently, surgical management of hepatocellular carcinoma should be addressed for non-viral hepatitis and liver cirrhosis. We attempt to apply liver replacement therapy using hepatocyte transplantation for clinical therapy. In order to achieve it, we developed rat liver replacement model which imitated clinical human NASH/NAFLD. In this model, we revealed a cell physiology of the transplanted cells which generated bile duct linage cells. In addition, we succeded to increase survival rate in NASH liver cirrhotic model. In the clinical research, we reported a benefit and default of donor cell procurement. We also revealed that a clinical value of BTR, ATIII, and GSA. We classified various liver functional indicators using clustering analysis.