Homeobox B9 induces EMT-associated radioresistance by accelerating DNA damage responses

同源盒 B9 通过加速 DNA 损伤反应诱导 EMT 相关的放射抗性

• 批准号: 23791499
• 负责人: HAYASHIDA Tetsu
• 金额: $ 2.75万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791499/
• 关键词: 乳癌; HOXB9; TGFβ; 放射線; ATM; EMT; 放射線耐性

We show that HOXB9 confers resistance to ionizing radiation by promoting DNA damage response. In non-irradiated cells, HOXB9 induces spontaneous DNA damage, phosphorylated histone 2AX and p53 binding protein 1 foci, and increases baseline ataxia telangiec

我们发现HOXB 9通过促进DNA损伤反应而赋予对电离辐射的抗性。在未照射的细胞中，HOXB 9诱导自发性DNA损伤、磷酸化组蛋白2AX和p53结合蛋白1灶，并增加基线共济失调毛细血管细胞凋亡。

项目成果

Direct inhibition of the transforming growth factor-β pathway by protein-bound polysaccharide through inactivation of Smad2 signaling

• DOI: 10.1111/j.1349-7006.2011.02133.x
• 发表时间: 2012-02-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Ono, Yoshihiro;Hayashida, Tetsu;Kitagawa, Yuko
• 通讯作者: Kitagawa, Yuko

Homeobox B9: a potential surrogate marker for bevacizumab in combination with chemotherapy in colorectal cancer

同源框 B9：贝伐珠单抗联合化疗治疗结直肠癌的潜在替代标志物

• 发表时间: 2012
• 作者: Hayashida T;Jinno H;Kitagawa Y;Kitajima M;林田哲;Tetsu Hayashida;林田哲;林田哲;星野好則;Yoshinori Hoshino
• 通讯作者: Yoshinori Hoshino

Homeobox B9: A potential surrote marker for bevacizumab in combination with chemotherapy in colorectal cancer

同源框 B9：贝伐珠单抗联合化疗治疗结直肠癌的潜在替代标志物

• 发表时间: 2012
• 作者: Hayashida T;Jinno H;Kitagawa Y;Kitajima M;林田哲;Tetsu Hayashida;林田哲;林田哲;星野好則;Yoshinori Hoshino;Tetsu Hayashida
• 通讯作者: Tetsu Hayashida

Homeobox B9: a potential surrogate marker for bevacizumab in combination with chemotherapy incolorectal cancer

同源框 B9：贝伐珠单抗联合化疗治疗结直肠癌的潜在替代标志物

• 发表时间: 2012
• 作者: Hayashida T;Jinno H;Kitagawa Y;Kitajima M;林田哲;Tetsu Hayashida;林田哲;林田哲;星野好則
• 通讯作者: 星野好則

EMT・血管新生からみたSeed & Soil Theoryと固形癌個別化治療

EMT/血管生成视角下的种子与土壤理论与实体瘤个体化治疗

• 发表时间: 2011
• 作者: Hayashida T;Jinno H;Kitagawa Y;Kitajima M;林田哲;Tetsu Hayashida;林田哲;林田哲;星野好則;Yoshinori Hoshino;Tetsu Hayashida;林田 哲;Hirohito Seki;関大仁;林田哲;林田哲
• 通讯作者: 林田哲