The inhibition effects of the Kynurenine pathway on brain tumor stem cells and its niche.

犬尿氨酸通路对脑肿瘤干细胞及其生态位的抑制作用。

• 批准号: 23791601
• 负责人: MIYAZAKI Takeshi
• 金额: $ 2.33万
• 依托单位: Shimane University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791601/
• 关键词: glioblastoma; brain tumor stem cells; Kynurenine pathway; cancer stem cell; kynurenine pathway; IDO; glioma; stem cells

Immunohistological examination revealed that Indoleamine 2,3 dioxygenase(IDO) positive cells in glioblastoma(GBM) tissue overlap the cells which construct the characteristic structure indicating GBM. The sphere cells (brain tumor stem cells: BTSC) enriched by the sphere culture method from the GBM patient showed high IDO reactivity on not only level of gene expression but also the enzyme activity compared with diffenretiated cells from sphere cells by serum stimulation. These data support IDO targeted strategy for BTSC in GBM treatment will be highly effective coupled with the fact that IDO inhibition may restore host's immune response against GBM.

免疫组织学检查表明，胶质母细胞瘤（GBM）组织中的吲哚胺2,3二氧酶（IDO）阳性细胞重叠的细胞构建了指示GBM的特征结构。由GBM患者的球体培养方法富集的球细胞（脑肿瘤干细胞：BTSC）在基因表达水平上，而且与从球体细胞中通过血清刺激相比，酶活性不仅在基因表达水平，而且在基因表达水平上显示出较高的IDO反应性。这些数据支持IDO在GBM治疗中的BTSC的目标策略将非常有效地结合IDO抑制可能会恢复宿主对GBM的免疫反应。

项目成果

グリオーマにおけるIndoleamine 2,3-dioxygenase発現と局在の意義

吲哚胺2,3-双加氧酶在神经胶质瘤中表达和定位的意义

• 发表时间: 2012
• 作者: 宮嵜健史;ら
• 通讯作者: ら

神経膠腫におけるIndoleamine 2,3-dioxygenase発現と局在

吲哚胺2,3-双加氧酶在神经胶质瘤中的表达和定位

• 发表时间: 2012
• 作者: 宮嵜健史;ら
• 通讯作者: ら