Beta oscillatory activity of single neurons in the subthalamic nucleus in patients with Parkinson's disease

帕金森病患者丘脑底核单个神经元的β振荡活动

• 批准号: 23791616
• 负责人: KOBAYASHI Kazutaka
• 金额: $ 2.66万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791616/
• 关键词: パーキンソン病; 脳深部刺激療法; 微小電極記録; STN; オシレーション

We analyzed the frequencies of single neurons of subthalamic nucleus (STN) in patients with advanced Parkinson's disease (PD). The neurons were classified as beta-band neurons and nonoscillatory neurons. Firing rates, distributions within the STN, and the proportions of kinesthetic neurons were compared between the 2 groups.The firing rate of beta-band neurons was significantly higher than that of nonoscillatory neurons. Beta-band neurons were widely distributed within the STN, and there was no significant intergroup difference in neuron distribution between the dorsal STN and the ventral STN. We did not note any significant intergroup difference in the proportion of kinesthetic neurons.The higher firing rate of beta-band neurons was consistent with the firing rate model of akinesia. The dorsal STN is a motor area, but the beta-band activity of a single neuron may not specifically reflect the motor symptoms of PD because of the wide distribution of beta-band neurons.

我们分析了晚期帕金森氏病（PD）患者中丘脑核（STN）的单神经元的频率。神经元分类为β波段神经元和非振荡神经元。比较了两组之间的发射速率，STN内的分布以及运动神经元的比例。β波段神经元的发射速率明显高于非振荡性神经元的发射速率。 β波段神经元在STN内广泛分布，并且背侧STN和腹侧STN之间的神经元分布没有显着的差异。我们没有注意到运动觉神经元比例的群体间差异有显着的差异。β波段神经元的发射速率较高，与Akinesia的点火速率模型一致。背侧STN是运动区域，但是由于β波段神经元的分布较大，单个神经元的β波段活性可能无法特别反映PD的运动症状。

项目成果

Beta oscillatory activity of single neurons in the subthalamic nucleus in patients with Parkinson's disease

帕金森病患者丘脑底核单个神经元的β振荡活动

• 发表时间: 2013
• 作者: Kobayashi K;Watanabe M;Sumi K;Obuchi T;Kano T;Oshima H;Fukaya C;Yoshino A;Yamamoto T;Katayama Y.
• 通讯作者: Katayama Y.

(Keynote Address: The Neurophysiology of Functional Neurosurgery) Pathological Subthalamic Nucleus Activity in Parkinson’s Disease

（主题演讲：功能神经外科的神经生理学）帕金森病的病理性底丘脑核活动

• 作者: Kobayashi K;Katayama Y
• 通讯作者: Katayama Y

Beta oscillatory activity in STN : Single cell recording study

STN 中的 Beta 振荡活动：单细胞记录研究

• 发表时间: 2013
• 作者: Kobayashi K;Katayama Y.;田中雅樹,永根基雄(永井良三,大田健(総編));上利 崇;Kazutaka K.
• 通讯作者: Kazutaka K.

ヒト脳内単一ニューロン活動分析による脳機能、不随意運動症の病態

通过分析人脑中单个神经元的活动来了解不自主运动障碍的脑功能和病理学

• 发表时间: 2011
• 作者: Kanno H;Nishihara H;Wang L;Yuzawa S;Kobayashi H;Tsuda M;Kimura T;Tanino M;Terasaka S;Tanaka S;小林一太
• 通讯作者: 小林一太

Beta oscillatory activity of single neurons in the subthalamic nucleus in patients with Parkinson’s disease

帕金森病患者丘脑底核单个神经元的β振荡活动

• 作者: Kobayashi K;Katayama Y
• 通讯作者: Katayama Y