The integrated search of mesenchymal stem cell fate determination of differentiation controlled by micro RNAs

在这项研究中，我们发现了一个受转录因子Osterix转录调控的microRNA，它对成骨细胞的分化具有关键作用。我们发现这种微小的RNA以促进成骨细胞分化和抑制其功能的基因为靶标，并且这种微小的RNA本身的转录受到Osterix的负调控。此外，我们还发现，这种微小的RNA负向调节成骨细胞的分化。因此，在本研究中，我们发现了一种能够调控间充质干细胞向成骨细胞分化的微RNA。这一发现进一步有助于理解微RNA在骨质疏松症和肥胖症等生活型疾病中的致病机制。

In this study, we identified a microRNA which are transcriptionally regulated by the transcription factor osterix that have critical roles for osteoblast differentiation. We identified that this micro RNA targets the genes which promote osteoblast differentiation and inhibit their function, and transcription of this micro RNA itself is negatively regulated by osterix. Moreover, we also found that this micro RNA negatively regulates osteoblast differentiation. Therefore, in this study we found a micro RNA that could regulate the fate of mesenchymal stem cells for osteoblast differentiation. This finding further contributes the understanding of pathogenic mechanisms with micro RNAs to the life-style diseases such as osteoporosis and obesity.