Clarification of urination sensor system of the mouse bladder epithelia

点击翻译按钮获取中文摘要

Common characters of known urination sensors are calcium channels and acid sensitivity. We gave acid stimuli to the mouse bladder epithelia under the condition that these channels were inhibited completely, and found calcium concentration increase of the cell inside by the stimulation pH < 5. It was suggested that this phenomenon was caused by the calcium entry from out of cells via calcium channel(s). The bladder epithelial cell response to acid stimuli was not observed in esophagus epithelial cells, that is, these findings indicated that the response mechanism to acid is specific to bladder epithelial cells.