An individual diagnosis of uterine cancer stem cells by SNP analysis

通过SNP分析对子宫癌干细胞进行个体化诊断

• 批准号: 23791854
• 负责人: NOMURA HIROYUKI
• 金额: $ 2.66万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791854/
• 关键词: 一塩基多型; 化学療法; 効果予測; 子宮体癌; 卵巣癌

Single nucleotide polymorphisms (SNPs) analysis is expected as the personalized medicine in pharmacotherapy. In this study, we attempted to extract SNPs correlated with drug response of adjuvant chemotherapy for uterine cancer as an individual diagnosis of cancer stem cells.A comprehensive SNP analysis was conducted, and specific SNPs on drug metabolism genes were identified. These SNPs may be useful in predicting toxicities as well as effects of chemotherapy.An individual diagnosis of cancer stem cells based on genomic information could apply to a new personalized treatment for uterine and other cancers.

单核苷酸多态性（SNPs）分析有望成为药物治疗中的个体化药物。本研究尝试提取与子宫癌辅助化疗药物反应相关的SNPs，作为肿瘤干细胞的个体化诊断指标，进行全面的SNP分析，筛选出药物代谢相关基因的特异性SNPs。这些SNPs可能有助于预测化疗的毒性和效果。基于基因组信息的癌症干细胞个体诊断可能适用于子宫癌和其他癌症的新的个性化治疗。

项目成果

The significance of measurement of cell free DNA in the endometrial cancer

子宫内膜癌中细胞游离DNA检测的意义

• 发表时间: 2011
• 作者: Tanaka H;Tsuda H;Nomura H;Kataoka F;Hirasawa A;Chiyoda T;Susumu N;Aoki D
• 通讯作者: Aoki D

子宮体がんの術後再発リスク評価と術後療法

子宫内膜癌术后复发风险评估及术后治疗

• 发表时间: 2013
• 期刊: 臨床婦人科産科
• 作者: 細野覚代;松尾恵太郎;伊藤秀美;田中英夫;細野覚代;進伸幸,山上亘,野村弘行,阪埜浩司,青木大輔
• 通讯作者: 進伸幸,山上亘,野村弘行,阪埜浩司,青木大輔

CANCER OF THE UTERINE ENDOMETRIUM - ADVANCES AND CONTROVERSIES

子宫内膜癌 - 进展与争议

• 发表时间: 2012
• 作者: Susumu N;Nomura H;Yamagami W;Hirasawa A;Banno K;Tsuda H;Sagae S;Aoki D
• 通讯作者: Aoki D

Association between drug response and gene polymorphisms in first-line chemotherapy for ovarian cancer

卵巢癌一线化疗药物反应与基因多态性的关联

• 发表时间: 2013
• 作者: Nomura H ;Kataoka F;Chiyoda T;Tanaka H;Hashimoto S;Arima H;Yamagami W;Tominaga E;Susumu N;Aoki D
• 通讯作者: Aoki D

A gene expression profile as a predictor of recurrence in low and intermediate-risk endometrial cancer

基因表达谱作为低风险和中风险子宫内膜癌复发的预测因子

• 发表时间: 2011
• 作者: Tsuda H;Ito Y;Tanaka H;Takano M,Nishimura S;Kataoka F;Nomura H;Chiyoda T;Hirasawa A;Susumu N;Aoki D
• 通讯作者: Aoki D