Regeneration of retinal function using human amnion cell-derived neural progenitors.

使用人羊膜细胞来源的神经祖细胞再生视网膜功能。

• 批准号: 23792013
• 负责人: KITAHARA Yuki
• 金额: $ 2.75万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23792013/
• 关键词: 再生医学; 網膜再生; 神経幹細胞; 羊膜由来幹細胞; 羊膜多能幹細胞; 羊膜由来多能性幹細胞

Human amniotic membrane is already broadly transplanted to the ocular surface , the supply is abundant and is easy to obtain. Human amnion cell-derived neural progenitors can be isolated and cultured from human amnion obtained during cesarean section under the informed consent. Human amnion cell-derived neural progenitors obtain long-term survival in the subretinal space and possess the potential of differentiating to retinal cells. Regeneration of retinal function was suggestive using electroretinogram.

人羊膜已被广泛移植到眼表，供应充足，容易获得。人羊膜细胞源性神经祖细胞可以在知情同意的情况下从剖宫产时获得的人羊膜中分离和培养。人羊膜细胞来源的神经前体细胞在视网膜下腔获得长期存活，并具有分化为视网膜细胞的潜力。视网膜电图提示视网膜功能再生。