Novel therapeutic strategy for oral squamous cell carcinoma by targeting angiogenesis signal.

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We investigated the effect of sodium butyrate (SB), one of histone deacetylase inhibitor on VEGF family expression in oral cancer cell line, HSC-3. Moreover, we investigated the effect of several inhibitors for AP-1, AKT and mTOR on VEGF family expression under SB stimulation.There are minimal difference in VEGF-A mRNA expression level between control and SB treated groups, however, we identified decrease of VEGF-B VEGF-C and VEGF-D mRNA expression. Moreover, angiogenic factor, angiopoientin-2 and platelet derived growth factor beta mRNA were decreased by SB treatment. These data suggest that SB inhibits stromal inducement in invasive oral carcinoma.