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Influence of histon deacetyrase inhibitor in induction of tumor-associated stroma in oral cancer cell line.

Influence of histon deacetyrase inhibitor in induction of tumor-associated stroma in oral cancer cell line.
组蛋白脱乙酰酶抑制剂对口腔癌细胞系中肿瘤相关基质诱导的影响。
批准号:
20791344
负责人:
MATSUMOTO Naoyuki
金额:
$1.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009

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中文摘要
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英文摘要
We investigated the effect of sodium butyrate (SB), one of histone deacetylase inhibitor on oral cancer cells. RNA and protein expression level of angiogenic- and lymphangiogenic-factors are assessed. Expression level of angiopoietin-2, platelet derived growth factor beta, VEGF-C, VEGF-D are downregulated by SB stimulation. These findings indicating its potential use in anti-angiogenic and -lymphangiogenic cancer therapy. Interestingly, agiogenic factor VEGF-A and transcription regulator COX-2 are upregulated. Now, we investigated detail of the mechanism.
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COX-2 high expression in the oral squamous epithelium relate to keratinocyte dif ferentiation but not for cell nroliferation
口腔鳞状上皮中COX-2的高表达与角质形成细胞分化有关,但与细胞增殖无关
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Komiyama K, Matsumoto N, et.al.]
通讯作者: et.al.
Generation of salivary gland-specific injury model mouse and elucidation of repair mechanism by EGFR2 / MUC1 pathway
  • 批准号:
    17K11633
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.66万
  • 财政年份:
    2017
  • 负责人:
    MATSUMOTO Naoyuki
  • 依托单位:
Development of detection system of oncogene expression
  • 批准号:
    25462934
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.24万
  • 财政年份:
    2013
  • 负责人:
    MATSUMOTO Naoyuki
  • 依托单位:
Development of guided tissue regeneration membrane with the control of nanoscale surface structure
  • 批准号:
    25463061
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.24万
  • 财政年份:
    2013
  • 负责人:
    MATSUMOTO Naoyuki
  • 依托单位:
Effects of the period of time of exercise and the fat/carbohydrate ratio of the food on the hippocampal neurogenesis.
  • 批准号:
    24500794
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.33万
  • 财政年份:
    2012
  • 负责人:
    MATSUMOTO Naoyuki
  • 依托单位:
海外基金