Influence of histon deacetyrase inhibitor in induction of tumor-associated stroma in oral cancer cell line.
Influence of histon deacetyrase inhibitor in induction of tumor-associated stroma in oral cancer cell line.
批准号:
20791344
负责人:
MATSUMOTO Naoyuki
金额:
$1.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
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英文摘要
We investigated the effect of sodium butyrate (SB), one of histone deacetylase inhibitor on oral cancer cells. RNA and protein expression level of angiogenic- and lymphangiogenic-factors are assessed. Expression level of angiopoietin-2, platelet derived growth factor beta, VEGF-C, VEGF-D are downregulated by SB stimulation. These findings indicating its potential use in anti-angiogenic and -lymphangiogenic cancer therapy. Interestingly, agiogenic factor VEGF-A and transcription regulator COX-2 are upregulated. Now, we investigated detail of the mechanism.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
COX-2 high expression in the oral squamous epithelium relate to keratinocyte dif ferentiation but not for cell nroliferation
口腔鳞状上皮中COX-2的高表达与角质形成细胞分化有关,但与细胞增殖无关
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Komiyama K, Matsumoto N, et.al.]
通讯作者:
et.al.
Generation of salivary gland-specific injury model mouse and elucidation of repair mechanism by EGFR2 / MUC1 pathway
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批准号:17K11633
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.66万
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财政年份:2017
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负责人:MATSUMOTO Naoyuki
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依托单位:
Development of detection system of oncogene expression
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批准号:25462934
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2013
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负责人:MATSUMOTO Naoyuki
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依托单位:
Development of guided tissue regeneration membrane with the control of nanoscale surface structure
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批准号:25463061
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2013
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负责人:MATSUMOTO Naoyuki
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依托单位:
Effects of the period of time of exercise and the fat/carbohydrate ratio of the food on the hippocampal neurogenesis.
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批准号:24500794
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.33万
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财政年份:2012
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负责人:MATSUMOTO Naoyuki
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依托单位:
Novel therapeutic strategy for oral squamous cell carcinoma by targeting angiogenesis signal.
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批准号:23792154
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2011
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负责人:MATSUMOTO Naoyuki
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依托单位:
Development of the bone substitute material for alveolar bone regeneration during tooth movement
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批准号:22592306
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2010
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负责人:MATSUMOTO Naoyuki
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依托单位:
Enhance of bone-implant interface using membrane techinique
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批准号:07557275
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$0.58万
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财政年份:1995
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负责人:MATSUMOTO Naoyuki
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依托单位:
Development of Osteoinductive Biomaterials (Purification of Osteoinductive Factor and Its Basic Research for Clinical Application)
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批准号:01480451
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.16万
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财政年份:1989
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负责人:MATSUMOTO Naoyuki
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依托单位:
A Study on Pressure Distribution of Supporting Tissues under Upper Complete Denture
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批准号:62480391
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$2.82万
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财政年份:1987
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负责人:MATSUMOTO Naoyuki
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依托单位:
Studies on the method of the reinforcement in the resin base
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批准号:60460217
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$2.69万
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财政年份:1985
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负责人:MATSUMOTO Naoyuki
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依托单位:
海外基金