Influence of histon deacetyrase inhibitor in induction of tumor-associated stroma in oral cancer cell line.

组蛋白脱乙酰酶抑制剂对口腔癌细胞系中肿瘤相关基质诱导的影响。

• 批准号: 20791344
• 负责人: MATSUMOTO Naoyuki
• 金额: $ 1.58万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791344/
• 关键词: 癌; リンパ管新生; 血管新生; 腫瘍問質誘導; DNA転写調節; 転移; 腫瘍間質誘導

We investigated the effect of sodium butyrate (SB), one of histone deacetylase inhibitor on oral cancer cells. RNA and protein expression level of angiogenic- and lymphangiogenic-factors are assessed. Expression level of angiopoietin-2, platelet derived growth factor beta, VEGF-C, VEGF-D are downregulated by SB stimulation. These findings indicating its potential use in anti-angiogenic and -lymphangiogenic cancer therapy. Interestingly, agiogenic factor VEGF-A and transcription regulator COX-2 are upregulated. Now, we investigated detail of the mechanism.

我们研究了组蛋白脱乙酰酶抑制剂之一丁酸钠（SB）对口腔癌细胞的影响。评估血管生成因子和淋巴管生成因子的RNA和蛋白质表达水平。血管生成素-2、血小板衍生生长因子β、VEGF-C、VEGF-D 的表达水平因SB 刺激而下调。这些发现表明其在抗血管生成和淋巴管生成癌症治疗中的潜在用途。有趣的是，血管生成因子 VEGF-A 和转录调节因子 COX-2 上调。现在，我们研究了该机制的细节。

项目成果

COX-2 high expression in the oral squamous epithelium relate to keratinocyte dif ferentiation but not for cell nroliferation

口腔鳞状上皮中COX-2的高表达与角质形成细胞分化有关，但与细胞增殖无关

• 发表时间: 2008
• 作者: Komiyama K;Matsumoto N;et.al.
• 通讯作者: et.al.