Enhance of bone-implant interface using membrane techinique

使用膜技术增强骨-种植体界面

• 批准号: 07557275
• 负责人: MATSUMOTO Naoyuki
• 金额: $ 0.58万
• 依托单位: THE UNIVERSITY OF TOKUSHIMA
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07557275/
• 关键词: GBR technique; resorbable membrane; true bone ceramics; new bone formation; space making; アパタイトインプラント; メンブレン

Clinical application of bone augmentation using the guided bone regeneration (GBR) techinique has been discused for last decade. In this study, we investigated new bone formation around the apatite implant uising a membrane technique. Apatite 2-Piece implants were inserted in tibiae of male New Zealand white rabbits and then covered with resorbable membranes (GC membrane, GC,Tokyo, Japan). Experimental groups were divided into two groups. In one group (EL groups), true bone ceramics connected by collagen gel (Bone Ject, Fujisawa, Tokyo, Japan) were placed between bone surface and membrane, In the other groups (E2 groups), true bone ceramics were not placed. In control groups, neither membrane or true bone ceramics was applied. Animals were sacrificed after two, four eight weeks. The specimens containing the implant and peripheral tissue were prepared for the histological examination. The results were the following :1) In E1 groups, the spaces aquired by application of the membranes were almost filled with new bone faster than those in control groups.2) In E2 groups, the spaces aquired by application of the membranes were filled with new bone slower than those in E1 groups. On eight weeks later, however, the spaces aquired were almost filled with new bone.3) On eight weeks later, mebranes kept their shape with a little destruction.4) New bone formation delayd by the use of true bone ceramics, however, those were effective for space making.

近十年来，引导骨再生(GBR)技术在骨移植中的临床应用已被广泛讨论。在这项研究中，我们使用膜技术研究了磷灰石种植体周围的新骨形成。将磷灰石两片种植体植入雄性新西兰大白兔的胫骨内，然后覆盖可吸收膜(GC膜，GC，日本东京)。试验组分为两组。其中一组(E1组)置入胶原凝胶连接的真骨陶瓷(日本东京藤泽的bone Ject)，另一组(E2组)不放置真骨陶瓷。对照组既不使用膜，也不使用真骨陶瓷。两周、四周、八周后处死动物。标本包括种植体和周围组织，用于组织学检查。结果如下：1)与对照组相比，E1组贴膜后空隙几乎快于新骨充填；2)E2组贴膜后空隙内新骨充盈的速度较E1组慢。然而，8周后，所获得的空隙几乎被新骨填满。3)8周后，膜保持其形状，但略有破坏。4)使用真正的骨陶瓷延缓了新骨的形成，但这些都是有效的空间创造。