Development of the bone substitute material for alveolar bone regeneration during tooth movement

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Implantable scaffolds of the chemical synthesis of collagen model polypeptides consisting of a Pro-Hyp-Gly [poly(PHG)] sequence for tissue regeneration need to be biodegradable, have no ability to induce inflammation and to act as a scaffold for cell proliferation and differentiation. The combining poly(PHG) and alpha-tricalcium phosphate particles, or mesenchymal stem cells showed extremely rapid bone regeneration in a calvarial defect model in mini-pigs.