Development of the bone substitute material for alveolar bone regeneration during tooth movement

牙齿移动期间牙槽骨再生的骨替代材料的开发

• 批准号: 22592306
• 负责人: MATSUMOTO Naoyuki
• 金额: $ 2.83万
• 依托单位: Osaka Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592306/
• 关键词: 歯科矯正学; 生体材料学; 組織工学; 人工コラーゲン; α-TCP; 生体吸収材料; 歯周組織再生; 歯槽骨再生

Implantable scaffolds of the chemical synthesis of collagen model polypeptides consisting of a Pro-Hyp-Gly [poly(PHG)] sequence for tissue regeneration need to be biodegradable, have no ability to induce inflammation and to act as a scaffold for cell proliferation and differentiation. The combining poly(PHG) and alpha-tricalcium phosphate particles, or mesenchymal stem cells showed extremely rapid bone regeneration in a calvarial defect model in mini-pigs.

用于组织再生的由pro - hy - gly [poly(PHG)]序列组成的胶原模型多肽的化学合成可植入支架需要可生物降解，不具有诱导炎症的能力，并作为细胞增殖和分化的支架。聚磷酸三钙颗粒或间充质干细胞在小型猪颅骨缺损模型中表现出极快的骨再生速度。

项目成果

Bone regeneration efficacy of bone marrow-derived mesenchymal stem cells in a 3-D woven fabric composite scaffold.

3-D 编织织物复合支架中骨髓来源的间充质干细胞的骨再生功效。

• 发表时间: 2011
• 期刊: Journal of Osaka Dental University 42(2)
• 作者: Kana Sakai;Yoshiyuki Arima;Kenichirou Yasui;Tomoko Kojima;Fumito Sakamoto;Yoshiya Hashimoto;Shunsuke Baba;Naoyuki Matsumoto
• 通讯作者: Naoyuki Matsumoto

Efficacy of bone regeneration with Poly(pro-hyp-gly)synthetic polypeptide sponge as scaffold using bone marrow derived mesenchymal stem cells.

使用骨髓间充质干细胞以聚（前-甘氨酸）合成多肽海绵作为支架的骨再生功效。

• 发表时间: 2011
• 期刊: Journal of Oral Tissue Engin 8(3)
• 作者: Daisuke Kimura;Shunsuke Baba;Masatoshi Ueda
• 通讯作者: Masatoshi Ueda

ポーラスα-リン酸三カルシウム/アテロコラーゲンスポンジ複合体のラット頭蓋冠骨欠損での骨再性能の評価

多孔α-磷酸三钙/胶原海绵复合材料对大鼠颅骨骨缺损的骨再生性能评价

• 发表时间: 2012
• 作者: Shunsuke Baba;Takeomi Inoue;YoshiyaHashimoto;Daisuke Kimura;Masatoshi Ueda;Kana Sakai;Naoyuki Matsumoto;Chiaki Hiwa;Taiji Adachi and Masaki Hojo;松本尚之;馬場俊輔;松本尚之;松本尚之;安井憲一郎,松本尚之,橋本典也,馬場俊輔,有馬良幸,坂本章人,本津茂樹;有馬良幸,安井憲一郎,坂本章人,上村直也,橋本典也,馬場俊輔,松本尚之;安井憲一郎,橋本典也,馬場俊輔,本津茂樹,松本尚之;有馬良幸,上村直也,橋本典也,松本尚之
• 通讯作者: 有馬良幸,上村直也,橋本典也,松本尚之

Effect of long acting nitric oxide donors on the differentiation of osteoclasts derived from mouse bone marrow macrophages

长效一氧化氮供体对小鼠骨髓巨噬细胞来源破骨细胞分化的影响

• 发表时间: 2010
• 期刊: Journal of Osaka Dental University
• 作者: Kaoru Inami;Hirofumi Sawai;Yuko Katao; Mika Shishido;Yousuke Ujii;Misa Shimozuma; Kensuke Nobata;Naochika Domae;Naoyuki Matsumoto
• 通讯作者: Naoyuki Matsumoto

Effects on bone regeneration when collagen model polypeptides are combined with various sizes of alpha-tricalcium phosphate particles.

• DOI: 10.4012/dmj.2011-126
• 发表时间: 2011-11
• 期刊: Dental materials journal
• 影响因子: 2.5
• 作者: Kana Sakai;Y. Hashimoto;S. Baba;Aki Nishiura;N. Matsumoto