Development of new dental pulp protection therapy by anti-inflammatory effect of catechin
Development of new dental pulp protection therapy by anti-inflammatory effect of catechin
批准号:
23792177
负责人:
HIRAO Kouji
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
Pulpitis, dental pulpal inflammation, is mainly associated with the dental caries-related pathogen invaded into dentinal tubles. Many types of cytokines and inflammatory mediators are induced for the initiation and progression of pulpitis. This study has demonstrated that HMGB1 and MINCLE were up-regulated by the stimulation with the ligands of innate immune receptors and the up-regulated expression of these mediators was inhibited by catechin. Moreover, this study was suggested that the binding of pathogen on cell surface receptors were inhibited by catechin.
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Prostaglandin F2alphaは歯髄細胞における炎症メディエーター発現を調節する
前列腺素 F2α 调节牙髓细胞炎症介质的表达
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[Masae Furukawa, Hisashi Hisamitsu and Atsufumi Manabe, 中西正]
通讯作者:
中西正
歯髄炎発症における自然免疫機構の役割と緑茶カテキンの歯髄炎抑制効果の検討
检查先天免疫系统在牙髓炎发展中的作用以及绿茶儿茶素对牙髓炎的抑制作用
DOI:
--
发表时间:
2012
期刊:
四国歯学会雑誌
影响因子:
--
作者:
[T. Furumoto, K. Nakatani, T. Ueda, A. Hosokawa and R. Tanaka, 田中玲奈,柴田 陽,真鍋厚史,宮崎 隆, 平尾功治]
通讯作者:
平尾功治
Prostaglandin F2-alpha Regukates Cytokine Expression in Dental Pulp Cells
前列腺素 F2-α 调节牙髓细胞中细胞因子的表达
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[重谷佳見, 大倉直人, 細矢明宏, 鈴木啓展, 吉羽邦彦, 吉羽永子, 大島勇人, 興地隆史, T Nakanishi]
通讯作者:
T Nakanishi
GENE EXPRESSION PROFILING OF HUMAN MONOCYTIC THP-1 CELLS STIMULATED WITH EXTRACELLULAR STREPTOCOCCUS INTERMEDIUS HISTON-LIKE DNA BINDING PROTEIN
用胞外中间链球菌组蛋白样 DNA 结合蛋白刺激的人单核 THP-1 细胞的基因表达谱
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Katsuhiko Hirota]
通讯作者:
Katsuhiko Hirota
ProstaglandinF2・は歯髄細胞における炎症性メディエーター発現を増強する
前列腺素 F2 增强牙髓细胞炎症介质表达
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Saruta Juri, Iida Michitaro, Kondo Yusuke, To Masahiro, Hayashi Takashi, Hori Mayumi, Sato Sadao, Tsukinoki Keiichi, 中西 正]
通讯作者:
中西 正
共 12 条
The analysis of odontoblastic mechanism via innate immune system
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批准号:15K11116
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2015
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负责人:HIRAO Kouji
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依托单位:
Functional analysis of Alarmin receptors in the pathogenesis of pulpitis
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批准号:25861803
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.5万
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财政年份:2013
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负责人:HIRAO Kouji
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依托单位:
海外基金