Establishment of dentin-pulp complex regeneration therapy from tolerance induced dental pulp tissues

牙髓对牙齿功能的维持起着重要的作用，因此，建立牙本质-牙髓复合体再生疗法是有益的。我们尝试了从离体牙髓中再生牙本质-牙髓复合体的策略。本研究发现，轻度热应激可诱导成牙本质细胞系细胞产生耐热性，热应激或BMP-2可促进成牙本质细胞向成牙本质细胞分化。这些发现有助于建立离断牙髓的牙本质-牙髓复合体再生疗法。

Dental pulp is important for maintenance of tooth function.Therefore, it is beneficial to establish the dentin-pulp complex regeneration therapy. Wehave tried to develop the strategy that regeneration of the dentin-pulp complex fromamputated dental pulp. In this study, we found that mild heat stress inducedthermo-resistance on odontoblastic lineage cells and heat stress or BMP-2 enhanced thatthe cells differentiated into odontoblast. These finding contributes to the establishment ofdentin-pulp complex regeneration therapy from amputated dental pulp.