Downregulation of Parathyroid Hormone Receptor 1 expression suppresses tumor metastasis in oral cancer.

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I. We examined the expression of PTHR1 mRNA and protein in oral cancer cell lines. PTHR1 is overexpressed in oral cancer cells.II. Comparing PTHR1 expression level, no correlation was found between oral cancer cell lines with high metastatic potential and those with low or non metastatic one.III. And cancer cells were strongly positive for PTHR1 staining in oral cancer clinical samples.IV. Moreover, the expression level of PTHR1 in cases with metastasis is higher than that of those with non metastasis.V. We established PTHR1 overexpressed oral cancer cell lines. The cell lines with high expression of PTHrP showed rapid growth.